Abstract: A flow modifying apparatus may include a plurality of struts coupled together to form a radially expandable frame having a proximal end and a distal end. The proximal and distal ends may be radially expandable into expanded proximal and distal ends. A reduced diameter portion of the expandable frame may be disposed between the expanded proximal and distal ends and the reduced diameter portion may comprise a fluid flow through passage. A cover may be disposed over at least a portion of the radially expandable frame. The reduced diameter portion modifies fluid flow therethrough immediately upon implantation thereof and forms a pressure gradient between the inflow end and the reduced diameter portion.

Abstract: An apparatus for cleaning an optical surface, at least a portion of the surface being covered by an optically transparent liquid film, includes a wiper including an edge extending across at least a portion of the optical surface and urged into close proximity with the optical surface, the edge being defined between a leading face and a trailing face. The apparatus also includes an actuator operable to move of at least one of the wiper and the optical surface to cause the wiper to traverse the optical surface such that the leading face dislodges contaminants entrained in the liquid film or adhered to the optical surface to produce a cleaned portion of the optical surface. The apparatus further includes a liquid applicator disposed behind the trailing face of the wiper and operable to dispense liquid for renewing the liquid film on the cleaned portion of the optical surface.

Abstract: A system comprised of a prosthetic heart valve device, and a delivery system. The prosthetic heart valve device comprises a differentially deformable anchoring structure concentrically aligned with, radially adjacent to, and in direct connection with a valve frame. The delivery system is comprised of a proximal control assembly connected to a first elongate, bendable catheter comprising a primary inner lumen, one or more secondary lumens adjacent to the primary lumen, one or more tethers releasably connected to the atrial portion of the prosthetic heart valve device, and a second elongate, bendable catheter with connection elements that are releasably connected to the ventricular portion of the prosthetic heart valve device.

Abstract: A flow modifying apparatus may include a plurality of struts coupled together to form a radially expandable frame having a proximal end and a distal end. The proximal and distal ends may be radially expandable into expanded proximal and distal ends. A reduced diameter portion of the expandable frame may be disposed between the expanded proximal and distal ends and the reduced diameter portion may comprise a fluid flow through passage. A cover may be disposed over at least a portion of the radially expandable frame. The reduced diameter portion modifies fluid flow therethrough immediately upon implantation thereof and forms a pressure gradient between the inflow end and the reduced diameter portion.

Abstract: Methods for the rapid retraction of trans-catheter heart valve delivery systems are provided. A rapid retraction trans-catheter heart valve delivery system comprises a catheter based delivery system. The delivery system has internal mechanisms that allow for the controlled deployment of a heart valve prosthesis, as well as mechanisms that allow for quickly closing the catheter once the heart valve prosthesis has been implanted. This rapid retraction ability allows for reduced procedural durations and thus reduced risk to the patient.

Abstract: Methods for the rapid retraction of trans-catheter heart valve delivery systems are provided. A rapid retraction trans-catheter heart valve delivery system comprises a catheter based delivery system. The delivery system has internal mechanisms that allow for the controlled deployment of a heart valve prosthesis, as well as mechanisms that allow for quickly closing the catheter once the heart valve prosthesis has been implanted. This rapid retraction ability allows for reduced procedural durations and thus reduced risk to the patient.

Abstract: Described herein are devices, systems, and methods for modifying blood flow and improving tissue oxygenation in an individual. More specifically, described herein are flow modifying implants, delivery systems, and methods of treatment using flow modifying implants. Also described herein are methods for preventing reperfusion injury in an individual using a flow modifying implant to prevent the reperfusion injury.

Abstract: A flow modifying apparatus may include a plurality of struts coupled together to form a radially expandable frame having a proximal end and a distal end. The proximal and distal ends may be radially expandable into expanded proximal and distal ends. A reduced diameter portion of the expandable frame may be disposed between the expanded proximal and distal ends and the reduced diameter portion may comprise a fluid flow through passage. A cover may be disposed over at least a portion of the radially expandable frame. The reduced diameter portion modifies fluid flow therethrough immediately upon implantation thereof and forms a pressure gradient between the inflow end and the reduced diameter portion.

Abstract: Methods for the rapid retraction of trans-catheter heart valve delivery systems are provided. A rapid retraction trans-catheter heart valve delivery system comprises a catheter based delivery system. The delivery system has internal mechanisms that allow for the controlled deployment of a heart valve prosthesis, as well as mechanisms that allow for quickly closing the catheter once the heart valve prosthesis has been implanted. This rapid retraction ability allows for reduced procedural durations and thus reduced risk to the patient.

Abstract: Methods for the rapid retraction of trans-catheter heart valve delivery systems are provided. A rapid retraction trans-catheter heart valve delivery system comprises a catheter based delivery system. The delivery system has internal mechanisms that allow for the controlled deployment of a heart valve prosthesis, as well as mechanisms that allow for quickly closing the catheter once the heart valve prosthesis has been implanted. This rapid retraction ability allows for reduced procedural durations and thus reduced risk to the patient.