Patents by Inventor Colin Andrew Leach

Colin Andrew Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine compounds
    Patent number: 6953803
    Abstract: Pyrmidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: October 11, 2005
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Colin Andrew Leach, Stephen Allan Smith
  • Pyrimidinone compounds
    Publication number: 20040167142
    Abstract: Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 26, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Resorufin derivatives as substrates for CYP3A4
    Patent number: 6762034
    Abstract: Resorufin derivative as a substance for cytochrome P450 enzyme.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: July 13, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Jacqueline Carol Bloomer, Richard Leonard Elliott, Colin Andrew Leach
  • Novel Compounds
    Publication number: 20040097525
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: October 27, 2003
    Publication date: May 20, 2004
    Applicant: SmithKline Beecham plc
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyridinone derivatives for treatment of atherosclerosis
    Publication number: 20040063753
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: September 9, 2003
    Publication date: April 1, 2004
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, John Liddle, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone derivatives and their use in the treatment of atherosclerosis
    Publication number: 20040058941
    Abstract: Compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating athereosclerosis.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 25, 2004
    Inventors: Richard Leonard Elliott, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Enzyme substrate
    Publication number: 20040014160
    Abstract: Coumarin derivative as a substrate for cytochrome P450 enzymes.
    Type: Application
    Filed: July 25, 2003
    Publication date: January 22, 2004
    Inventors: Jacqueline Carol Bloomer, Colin Andrew Leach
  • Compounds
    Patent number: 6649619
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone derivatives for the treatment of atherosclerosis
    Patent number: 6559155
    Abstract: Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA2 and thereof use in treating inter alia atherosclerosis, in which: R1 is COOH or a salt thereof, COOR10, CONR11R12, CN or CH2OH; R2 is a mono- or bicyclic aromatic ring system or a mono- or bicyclic heteroaromatic ring system; R3 is C1-20alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-5alkyl, C1-10alkoxyC1-10alkyl, or an aromatic or heteroaromatic ring system; W is SO2 or a bond; X is O or S; and Y is a group of the formula A1—A2—A3 in which A1 and A3 each represent a bond or a straight chain or branched alkylene group, said alkylene group(s) containing a total of 1 to 10 carbon atoms and A2 represents a bond or O, S, SO, SO2, CO, C═CH2, CONH, NHCO, CR15R16, CH═CH or C═C, providing that when A2 is O, S, SO, SO2 or CONH, A3 contains at least two carbon atoms linking the A2 group and the CH2 group in formula (I).
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: May 6, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Colin Andrew Leach, Stephen Allan Smith
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Publication number: 20020120139
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Application
    Filed: April 2, 2002
    Publication date: August 29, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Cinoxacin lanthanide chelates and their use as biomolecular probes
    Patent number: 6441167
    Abstract: This invention relates to novel compounds that can complex with lanthanide cations, processes for their preparation and the use of the resulting lanthanide chelates as biomolecular probes.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: August 27, 2002
    Assignee: SmithKline Beecham plc
    Inventors: Colin Andrew Leach, Keith James Millan Moore, Steven James Stanway
  • Novel compounds
    Publication number: 20020103213
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: February 14, 2001
    Publication date: August 1, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Patent number: 6417192
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: July 9, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Azetidinone derivatives for the treatment of atherosclerosis
    Patent number: 6071899
    Abstract: Azetidinone derivatives of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen or C.sub.(1-8) alkyl; R.sup.3 is C.sub.(1-8) alkyl or C.sub.(3-8) cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; and n is 0, 1 or 2; and excluding benzyl (4-methylthio-2-oxo-azetidin-1-yl)acetate are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: June 6, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Dashyant Dhanak, Colin Andrew Leach, Robert John Ife, David Graham Tew
  • Substituted azetidin-2-ones for treatment of atherosclerosis
    Patent number: 5990102
    Abstract: Compounds of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen, halogen or C.sub.(1-8) alkyl; R.sup.3 is aryl or aryl C.sub.(1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA.sub.2 and thereof of use in treating atherosclerosis.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: November 23, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Dashyant Dhanak, Colin Andrew Leach, Robert John Ife, David Graham Tew