Patents by Inventor Colin Brenan

Colin Brenan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190345537
    Abstract: The present invention concerns a method for capturing and barcoding nucleic acid from single cells, a plurality of microfluidic droplets and a method for preparing said plurality of microfluidic droplets.
    Type: Application
    Filed: December 8, 2016
    Publication date: November 14, 2019
    Inventors: Annabelle Patricia Véronique GERARD, Kévin Armand SELIN, Adeline Frédérique, Joëlle POITOU, Sami ELLOUZE, Yannick Michel, Louis POUSSE, Marcel REICHEN, Allan JENSEN, Colin Brenan
  • Publication number: 20180361345
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: May 14, 2018
    Publication date: December 20, 2018
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Patent number: 9968903
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 15, 2018
    Assignee: Life Technologies Corporation
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Publication number: 20160332133
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: April 18, 2016
    Publication date: November 17, 2016
    Inventors: Robert HESS, John LINTON, Tanya S. KANIGAN, Colin BRENAN, Can OZBAL
  • Patent number: 9428800
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: August 30, 2016
    Assignee: Life Technologies Corporation
    Inventors: John Linton, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Madrone, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Patent number: 9314764
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: April 19, 2016
    Assignee: Life Technologies Corporation
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Publication number: 20140179566
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Application
    Filed: March 3, 2014
    Publication date: June 26, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: John LINTON, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Patent number: 8697452
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 15, 2014
    Assignee: Life Technologies Corporation
    Inventors: John Linton, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Publication number: 20120245038
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Application
    Filed: June 8, 2012
    Publication date: September 27, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20120021951
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: July 21, 2011
    Publication date: January 26, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Publication number: 20110251084
    Abstract: The invention features compositions and methods that are useful for the detection of a target analyte, such as a pathogen, in a sample.
    Type: Application
    Filed: December 22, 2008
    Publication date: October 13, 2011
    Inventors: Colin Brenan, Thomas Morrison
  • Publication number: 20110003699
    Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
    Type: Application
    Filed: December 18, 2009
    Publication date: January 6, 2011
    Applicant: BioTrove, Inc.
    Inventors: Karl Yoder, Colin Brenan, John Linton, Leila Hasan, Robert Ellis, Arrin Katz, Tom Morrison, Jorge Fonseca
  • Publication number: 20100261159
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: August 10, 2006
    Publication date: October 14, 2010
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Patent number: 7682565
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: March 23, 2010
    Assignee: BioTrove, Inc.
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20090062152
    Abstract: A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.
    Type: Application
    Filed: October 1, 2008
    Publication date: March 5, 2009
    Applicant: BIOTROVE, INC.
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20090062134
    Abstract: A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.
    Type: Application
    Filed: October 3, 2008
    Publication date: March 5, 2009
    Applicant: BIOTROVE, INC.
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20070043341
    Abstract: A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system.
    Type: Application
    Filed: October 19, 2006
    Publication date: February 22, 2007
    Inventors: R. Anderson, Ian Hunter, Colin Brenan, Keng Lim, Elizabeth Sebern
  • Publication number: 20060105453
    Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.
    Type: Application
    Filed: August 4, 2005
    Publication date: May 18, 2006
    Inventors: Colin Brenan, Jamie Cho, Javier Garcia, Robert Hess, Tanya Kanigan, Arrin Katz, Namyong Kim, John Linton, Shailesh Srivastava, Karl Yoder
  • Publication number: 20060094108
    Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
    Type: Application
    Filed: September 15, 2005
    Publication date: May 4, 2006
    Inventors: Karl Yoder, Colin Brenan, John Linton, Leila Hasan, Robert Ellis, Arrin Katz, Tom Morrison, Jorge Fonseca
  • Publication number: 20050079105
    Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.
    Type: Application
    Filed: October 5, 2004
    Publication date: April 14, 2005
    Applicant: Massachusetts Institute of Technology
    Inventors: Ian Hunter, Colin Brenan, Tanya Kanigan