Abstract: In a first aspect, provided herein is a beta/MPZ family-subunit-eliminated (beta/MPZ?) engineered-cell comprising a cell with functionally inactivated SCN1B, SCN2B, SCN3B, SCN4B, MPZL1, MPZL2, MPZL3, MPZ and JAML genes. In certain aspects, the beta/MPZ? cell further comprising a defined engineered voltage-gated sodium channel, wherein the engineered voltage-gated sodium channel comprises a sodium channel alpha subunit, at least one sodium channel beta subunit.

Abstract: The present invention relates to a method and system for predicting performance of biopharmaceutical manufacturing processes by measuring a parameter of the biopharmaceutical manufacturing process at a predetermined sampling frequency, wherein said parameter is measured for n number of runs of said process, sequentially joining the parameter data of the n number of runs in a single continuous time-series manner, to generate a transformed data, training a time series analysis model for forecasting performance of the biopharmaceutical manufacturing process, based on a plurality of transformed data generated corresponding to a plurality of parameters, measuring the plurality of parameters at a predetermined timepoint, and using said measurement to reinforce and improve the trained time series analysis model, and predicting the plurality of parameters for a future run of the biopharmaceutical manufacturing process, based on the trained time series analysis model.

Abstract: A bathroom system includes a shower system, a sink system, a gray water tank, a toilet, a first conduit, and a second conduit. The shower system includes a drain ring configured to collect gray water from the shower system. The gray water tank includes an internal filtration system and is configured to filter and store gray water. The gray water tank is configured to introduce a chemical into the gray water and is configured to draw electrical power from a power supply. The first conduit is coupled to the gray water, it connects the shower system and the gray water tank, and it is configured to transfer the gray water from the drain ring to the gray water tank. The second conduit is configured to transfer the gray water from the gray water tank to the toilet to provide water for flushing.

Abstract: A system for and a method of supplying electrical power to a plurality of refrigerated containers. The method includes obtaining carriage criteria of one or more refrigerated containers, processing the carriage criteria in a central processor configured to control power supply to a plurality of refrigerated containers, on basis of output of the central processor, managing electrical power supply to the plurality of refrigerated containers.

Abstract: A controllable antenna system is disclosed. The system comprises a directional antenna configured to be directed in a selected direction. A radio frequency detector is configured to measure a power level of a signal. A control unit is configured to send a control signal to direct a directional antenna in a selected direction based on the measured power level to transmit or receive. A signal booster may be configured to reduce attenuation and/or increase signal quality of the signal.

Abstract: A method of configuring a signal booster may include receiving an indication that a first interface port of a first amplifier is configured such that external signals are not introduced to the first amplifier and measuring thermal noise output by the first amplifier at a second amplifier communicatively coupled to a second interface port of the first amplifier after receiving the indication. The method may further include determining signal loss between the first amplifier and the second amplifier based on the measured thermal noise and setting a gain of the second amplifier based on the signal loss.

Abstract: A signal booster may include first and second uplink gain units each configured to apply an uplink gain to an uplink signal. The signal booster may further include first and second downlink gain units each configured to apply a downlink gain to a downlink signal. The signal booster may also include a passive signal directing unit configured to communicatively couple the first uplink gain unit to the second uplink gain unit and to communicatively couple the first downlink gain unit to the second downlink gain unit.

Abstract: According to some embodiments described herein, a bi-directional amplifier may include a first interface port configured to receive a first signal. The bi-directional amplifier may also include a second interface port. The second interface port may be communicatively coupled to the first interface port and may be configured to receive a second signal. The second interface port may be communicatively coupled to the first interface port such that the first signal propagates from the first interface port to the second interface port and such that the second signal propagates from the second interface port to the first interface port. The bi-directional amplifier may also include a common amplifier communicatively coupled between the first interface port and the second interface port such that the common amplifier is configured to receive and amplify both the first signal and the second signal.

Abstract: A system for and a method of supplying electrical power to a plurality of refrigerated containers. The method includes the steps of: obtaining carriage criteria of one or more refrigerated containers, processing said carriage criteria in a central processor configured to control power supply to a plurality of refrigerated containers, on basis of output of said central processor, managing electrical power supply to said plurality of refrigerated containers.

Abstract: According to some embodiments described herein, a bi-directional amplifier may include a first interface port configured to receive a first signal. The bi-directional amplifier may also include a second interface port. The second interface port may be communicatively coupled to the first interface port and may be configured to receive a second signal. The second interface port may be communicatively coupled to the first interface port such that the first signal propagates from the first interface port to the second interface port and such that the second signal propagates from the second interface port to the first interface port. The bi-directional amplifier may also include a common amplifier communicatively coupled between the first interface port and the second interface port such that the common amplifier is configured to receive and amplify both the first signal and the second signal.

Abstract: A method of predicting response to thalidomide, or thalidomide analogs, in an individual with cancer, especially cancers for which thalidomide has been implicated as a treatment, such as Multiple Myeloma (MM) employs one or more of a panel of biomarkers that have been shown to be differentially expressed in cancer patients that respond to thalidomide (hereafter “Responders”) relative to cancer patients that do not respond to thalidomide (hereafter “Non-responders). The method involves assaying a biological sample from the individual to determine the abundance of at least three biomarkers including Vitamin-D binding protein precursor (VDB) (Sequence ID 1) and Serum amyloid A protein (SAA) (Sequence ID 3), and at least one of beta-2-microglobulin (B2M) (Sequence ID 4), Haptoglobin (Hp) precursor (fragment) (Sequence ID 5), and zinc-alpha-2-glycoprotein (ZAG) (Sequence ID 2).

Abstract: This disclosure describes a mattress having a plurality of vertically-oriented inflatable bladders and a pneumatic box located inside the mattress. In one embodiment, the patient support includes a plurality of pressure sensors positioned underneath the bladders. In still another embodiment, the patient support includes one or more filler portions that are selectable so that the patient support may conform to bed frames having different deck configurations.

Abstract: Provided herein are systems and methods that permit low resolution Raman spectroscopy to be used for detection of biological components within cells in order to classify the cells, for example, as premalignant, malignant, or benign.

Abstract: A patient support having real time pressure control. The patient support includes a plurality of sensors located beneath a bladder including a plurality of upright cylindrical elements. The pressure within the bladder is controlled based on the pressure or force sensed by the plurality of sensors.

Abstract: This disclosure describes certain exemplary embodiments of a patient support having a plurality of vertically-oriented or substantially can-shaped inflatable bladders. In one embodiment, the patient support includes a plurality of pressure sensors positioned underneath the bladders. In another embodiment, the patient support includes a support layer positioned above the vertical bladders. In still another embodiment, the patient support includes one or more filler portions that are selectable so that the patient support may conform to bed frames having different deck configurations.

Abstract: A body support such as a cushion, mattress, chair or the like has at least one inflatable air chamber. A pressure sensor senses interface pressures at different locations on a surface of the air chamber. Indicators derived from the interface pressures indicate the onset of a trend toward bottoming out. A controller controls air pressure within the air chamber based at least in part on values of the indicators. The controller may be implemented as a state machine.

Abstract: A body support such as a cushion, mattress, chair or the like has at least one inflatable air chamber. A pressure sensor senses interface pressures at different locations on a surface of the air chamber. Indicators derived from the interface pressures indicate the onset of a trend toward bottoming out. A controller controls air pressure within the air chamber based at least in part on values of the indicators. The controller may be implemented as a state machine.

Abstract: This disclosure describes certain exemplary embodiments of a patient support having a plurality of vertically-oriented on substantially can-shaped inflatable bladders. In one embodiment, the patient support includes a plurality of pressure sensors positioned underneath the bladders. In another embodiment, the patient support includes a support layer positioned above the vertical bladders. In still another embodiment, the patient support includes one or more filler portions that are selectable so that the patient support may conform to bed frames having different deck configurations.

Abstract: A flowmeter includes a vibratable flowtube that has internal damping characteristics that substantially result in a desired dynamic response of the vibratable tube to a change in a flow of fluid through the vibratable flowtube. The dynamic response may be to a change in a property of the flow of fluid, a step change in the flow, and/or a change in the mass flow rate. The vibratable flowtube may have frequency-dependent internal damping characteristics such that damping of a driven mode of vibration is not substantially increased and damping at one or more modes other than the driven mode are substantially increased.

Abstract: This disclosure describes certain exemplary embodiments of a patient support having a plurality of vertically-oriented on substantially can-shaped inflatable bladders. In one embodiment, the patient support includes a plurality of pressure sensors positioned underneath the bladders. In another embodiment, the patient support includes a support layer positioned above the vertical bladders. In still another embodiment, the patient support includes one or more filler portions that are selectable so that the patient support may conform to bed frames having different deck configurations.