Abstract: The present disclosure provides a three-dimensional micro-electrode that comprises an electrically conductive, elongate body with: a base that is electrically connectible to a recording system; a tip that is opposite the base and that is configured to establish electrical communication with an excitable cellular-network or a cell therein; and an elongate portion between the base and the tip. The elongate portion is covered with at least one layer of an electrical-insulator coating that extends from the base to proximal the tip. The present disclosure also provides a micro-electrode array comprising at least two three-dimensional micro-electrodes that are electrically connective to at least one recording system. The present disclosure also provides a method of making and using a three-dimensional micro-electrode and an array that comprises three-dimensional micro-electrodes.

Abstract: The present disclosure relates to an apparatus, system and method for inserting one or more probes into a subjects body for one or more purposes of acquiring physiological data or delivering a treatment into the subjects body.

Abstract: The present disclosure provides a three-dimensional micro-electrode that comprises an electrically conductive, elongate body with: a base that is electrically connectible to a recording system; a tip that is opposite the base and that is configured to establish electrical communication with an excitable cellular-network or a cell therein; and an elongate portion between the base and the tip. The elongate portion is covered with at least one layer of an electrical-insulator coating that extends from the base to proximal the tip. The present disclosure also provides a micro-electrode array comprising at least two three-dimensional micro-electrodes that are electrically connective to at least one recording system. The present disclosure also provides a method of making and using a three-dimensional micro-electrode and an array that comprises three-dimensional micro-electrodes.

Abstract: A flow monitoring device for monitoring mud flow in a return line of a bore hole drilling operation, including a mounting bracket mounted to the return line with a viewing port for access to an interior of the return line. A light source illuminates, through the viewing port, a portion of the mud flow in an observation zone within the return line. A camera creates a plurality of images of the mud flow in the observation zone. A controller is configured to analyze the plurality images to: determine a level of the mud flow in the return line and the presence of at least one irregularity, track a movement of the irregularity across the plurality of images to determine a rate of movement of the irregularity, and calculate a flow rate of the mud flow through the return line based on the movement rate and the determined level.

Abstract: A microelectrode or an array of microelectrodes for communicating with one or more adjacent electrically excitable cells. The microelectrode array comprises two or more microelectrodes. Each microelectrode comprises a body with a perimeter; an electrode wire that is electronically connected to the body and that is electronically connectible to an electronic system; and a ridge that extends away from the perimeter of the body for increasing a sealing-resistance value between the electrode and the one or more adjacent electrically excitable cells.

Abstract: A flow monitoring device for monitoring mud flow in a return line of a bore hole drilling operation, including a mounting bracket mounted to the return line with a viewing port for access to an interior of the return line. A light source illuminates, through the viewing port, a portion of the mud flow in an observation zone within the return line. A camera creates a plurality of images of the mud flow in the observation zone. A controller is configured to analyze the plurality images to: determine a level of the mud flow in the return line and the presence of at least one irregularity, track a movement of the irregularity across the plurality of images to determine a rate of movement of the irregularity, and calculate a flow rate of the mud flow through the return line based on the movement rate and the determined level.

Abstract: The present invention relates to efficient devices for administration of pharmaceutical agents into the skin of the human body. In particular the present invention provides devices for vaccination into the skin. The present invention provides a pharmaceutical agent delivery device having skin-piercing portion comprising a solid reservoir medium containing the pharmaceutical agent, wherein the reservoir medium is coated onto the skin piercing portion. Alternatively, the skin piercing portion may consist of the solid pharmaceutical agent reservoir medium. The pharmaceutical delivery devices are proportioned such that agent is delivered into defined layers of the skin, and preferred delivery devices comprise skin-piercing portions that deliver the pharmaceutical agent into the epithelium or the dermis. Preferred reservoir media comprise sugars, and in particular stabilising sugars that forms a glass such as lactose, raffinose, trehalose or sucrose.

Abstract: Indole compounds having utility as blood platelet aggregation inhibitors and as intermediates in the production of 1,4-benzodiazepines are disclosed.