Abstract: The present invention relates generally to the field of beverage capsules. In particular, the present invention relates to a biodegradable top membrane of a beverage capsules. The biodegradable top membrane of a beverage capsule is pierceable by injection means of a beverage preparation machine which are adapted to inject an extraction liquid under pressure inside a closed chamber containing a mass of soluble and/or extractable food material. Remarkably, the top membrane possesses the necessary physical properties to be useful for beverage capsules while being biodegradable. The biodegradable top membrane for a beverage capsule comprises at least one polyhydroxyalkanoate (PHA).

Abstract: Gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods for using such systems. The systems are characterized by use of a dispersant in the formulations, which improves the burst release characteristics and long-term release rate characteristics of the systems. Milling of therapeutic agent can also be performed to prepare agent particles of desired size.

Abstract: The invention provides gastric residence systems, or components of gastric residence system such as segments or elongate members of gastric residence systems, with release rate-modulating films and methods for making and using such systems. The release rate-modulating films provide good control over release of agents (such as therapeutic, diagnostic, or nutritional agents) present in the gastric residence system. The films also permit higher drug loading in the gastric residence systems and components of gastric residence systems while maintaining good control over release of agents. Some embodiments of the films can provide resistance against burst release of agent upon exposure to alcohol.

Abstract: The invention provides gastric residence systems with configurations and geometrical dimensions that allow for improved shelf life during prolonged storage, and optimal residence properties when the systems are deployed in the stomach of a patient.

Abstract: Gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods for using such systems. The systems are characterized by use of a dispersant in the formulations, which improves the burst release characteristics and long-term release rate characteristics of the systems. Milling of therapeutic agent can also be performed to prepare agent particles of desired size.

Abstract: Preformulation analysis and optimization comprising dissolution strudies.

Abstract: An effervescent formulation of alendronate contains an acid source, a carbonate source, a binder, a lubricant and optionally, flavoring agents, colorants and sweeteners.

Abstract: The present invention concerns a method, apparatus (array assembly), and system for fabricating and formulating hydrogels using combinatorial techniques; a hydrogel array fabricated using the method, apparatus, and/or system of the invention; and methods and systems for testing the properties of arrayed hydrogels, such as bulk and interfacial mechanical properties.

Abstract: Liquid formulations of celecoxib have been found to provide faster pain relief than conventional solid formulations of celecoxib. The present invention provides combinations of excipients in which celecoxib is highly soluble for formulation as pharmaceutical compositions.

Abstract: In a first aspect, the present invention includes a pharmaceutical composition comprising a COX-2 inhibitor and a diuretic. Such a composition can be used to treat a patient suffering from, for example, osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, pain, primary dysmenorrhea, migraine, or colorectal polyps. The disclosure provides methods as well as pharmaceutical compositions and formulations useful in the treatment and/or prevention of one or more of several conditions described herein.

Abstract: Preformulation analysis and optimization comprising dissolution strudies.

Abstract: An effervescent formulation of alendronate contains an acid source, a carbonate source, a binder, a lubricant and optionally, flavoring agents, colorants and sweeteners.

Abstract: A system and method for providing voice or data connectivity to multiple aircraft or communication devices via a single telephone number. The initial call placed by a caller can be to a direct global number, or can be forwarded to the direct global number via a toll-free access number. A caller is prompted to select from an automated selection of aircraft, vessels, communication devices, or other available devices or units. Based upon the selection, the call is routed to the single global number for that selection. A caller then hears a greeting that identifies the aircraft, vessel, or device selected and provides the handset, data service, or other options available. After a caller makes a selection, call connectivity is established.

Abstract: An automated communication system for communicatively connecting a caller with a communications device to an space craft. The system includes a port for accepting a call and a call management program that uses a spacecraft identifier to automatically effect the communication to the space craft via a ground earth station and a satellite. The satellite retransmits the communication to a dedicated spacecraft receiver in the space craft. The system provides Internet-based call monitoring and billing capabilities. The system reduces cost and overall connection time by using the Internet to verify the spacecraft's flying status through the ground station databases before initiating a call.

Abstract: Methods and systems are disclosed that can be used for the automated preparation and analysis of mixtures comprising a compound-of-interest (e.g., the active ingredient of a pharmaceutical composition) and one or more excipients. Specific embodiments of the invention are particularly suited for the precise preparation and screening of small amounts of excipients, compounds-of-interest, and mixtures thereof. The invention is also well suited for the preparation and screening of small amounts of mixtures comprising high concentrations of compounds-of-interest.

Abstract: An automated communication system for communicatively connecting a caller with a communications device to an space craft. The system includes a port for accepting a call and a call management program that uses a spacecraft identifier to automatically effect the communication to the space craft via a ground earth station and a satellite. The satellite retransmits the communication to a dedicated spacecraft receiver in the space craft. The system provides Internet-based call monitoring and billing capabilities. The system reduces cost and overall connection time by using the Internet to verify the spacecraft's flying status through the ground station databases before initiating a call.

Abstract: An automated communication system for communicatively connecting a caller by means of a telephone to an space craft includes a port for accepting a telephonic call related to a specific space craft from the caller and having a machine readable call management program, the call management program automatically effecting a telephonic communication to at least one selected ground earth station responsive thereto. The ground earth station effects communication with at least one known satellite in an earth orbit responsive to the received communication from the port. And, the satellite retransmits the ground earth station communications to the space craft for reception by a dedicated receiver in the space craft, thereby establishing a telephonic communications link from the caller to the specific space craft. A method and a program for effecting global communications between a ground station, a plurality of global satellite systems and a space craft are included.