Patents by Inventor Colin H. MacKinnon

Colin H. MacKinnon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    Publication number: 20160326142
    Abstract: Provided herein are compounds of formula (AA): stereoisomers or a pharmaceutically acceptable salt thereof, wherein A, Ra, p, R5 and R6 are defined herein, compositions including the compounds and methods of manufacturing and using the compounds for the treatment of diseases.
    Type: Application
    Filed: May 11, 2016
    Publication date: November 10, 2016
    Applicant: Genentech, Inc.
    Inventors: Jason BURCH, Frederick Brookfield, Richard A. Goldsmith, Kevin Hon Luen Lau, Colin H. MacKinnon, Daniel Fred Ortwine, Zhonghua Pei
  • PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    Publication number: 20150158851
    Abstract: Provided herein are compounds of formula (AA): stereoisomers or a pharmaceutically acceptable salt thereof, wherein A, Ra, p, R5 and R6 are defined herein, compositions including the compounds and methods of manufacturing and using the compounds for the treatment of diseases.
    Type: Application
    Filed: February 10, 2015
    Publication date: June 11, 2015
    Applicant: Genentech, Inc.
    Inventors: Jason Burch, Frederick Brookfield, Richard A. Goldsmith, Kevin Hon Luen Lau, Colin H. MacKinnon, Daniel Fred Ortwine, Zhonghua Pei
  • Mediators of hedgehog signaling pathways, compositions and uses related hereto
    Patent number: 8815895
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 26, 2014
    Assignees: Curis, Inc., Genentech, Inc.
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. Mackinnon
  • MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO
    Publication number: 20120283258
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: March 16, 2012
    Publication date: November 8, 2012
    Applicants: CURIS, INC., GENENTECH, INC.
    Inventors: Oivin M. GUICHERIT, Edward Andrew BOYD, Judith Boyd, Shirley Ann BRUNTON, Stephen PRICE, John Harry Alexander STIBBARD, Colin H. MACKINNON
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 8168653
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: May 1, 2012
    Assignees: Curis, Inc., Genentech, Inc.
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. Mackinnon
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20100317660
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: August 2, 2010
    Publication date: December 16, 2010
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Judith Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. Mackinnon
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 7816369
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: October 19, 2010
    Assignees: Curis, Inc., Genentech, Inc.
    Inventors: Oivin M. Guicherit, Edward Andrew Boyd, Judith Boyd, legal representative, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. MacKinnon
  • Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
    Publication number: 20090012082
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: November 3, 2005
    Publication date: January 8, 2009
    Applicant: CURIS, INC.
    Inventors: Olivin M. Guicherit, Edward Andrew Boyd, Judith Boyd, Shirley Ann Brunton, Stephen Price, John Harry Alexander Stibbard, Colin H. MacKinnon