Patents by Inventor Colin Hammond

Colin Hammond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules blocking histone reader domains
    Patent number: 10961289
    Abstract: The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: March 30, 2021
    Assignees: The University of Copenhagen, Memorial Sloan-Kettering Cancer Center
    Inventors: Anja Groth, Giulia Saredi, Hongda Huang, Colin Hammond, Dinshaw Patel
  • SMALL MOLECULES BLOCKING HISTONE READER DOMAINS
    Publication number: 20200148732
    Abstract: The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket.
    Type: Application
    Filed: November 29, 2019
    Publication date: May 14, 2020
    Inventors: Anja Groth, Giulia Saredi, Hongda Huang, Colin Hammond, Dinshaw Patel
  • SMALL MOLECULES BLOCKING HISTONE READER DOMAINS
    Publication number: 20180282383
    Abstract: The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket. The present inventors have identified and solved the structure of a histone reader domain of TONSL termed the ARD (ankyrin repeat domain).
    Type: Application
    Filed: September 30, 2016
    Publication date: October 4, 2018
    Inventors: Anja Groth, Giulia Saredi, Hongda Huang, Colin Hammond, Dinshaw Patel