Patents by Inventor Colin J. Nichols
Colin J. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7001379Abstract: Method for heating tissue by delivering radio frequency energy through tissue electrodes having controlling energy delivery so that an abrupt increase in impedance between the electrodes and the tissue is observed, typically in the form of an abrupt decrease in power delivered to the electrodes. The power at which the impedance increases and/or the time required to induce such an increase in impedance, are relied on to determine acceptable ranges to achieve a maximum sustainable delivery of radio frequency energy to the tissue consistent with complete, rapid, and uniform heating of the tissue.Type: GrantFiled: January 12, 2004Date of Patent: February 21, 2006Assignee: Boston Scientific Scimed, Inc.Inventors: Robert S. Behl, Eben L. Kermit, Peter F. Lyons, Colin J. Nichols
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Publication number: 20040147919Abstract: Methods for heating tissue by delivering radio frequency energy through tissue electrodes comprise controlling energy delivery so that an abrupt increase in impedance between the electrodes and the tissue is observed, typically in the form of an abrupt decrease in power delivered to the electrodes. The power at which the impedance increases and/or the time required to induce such an increase in impedance, are relied on to determine acceptable ranges to achieve a maximum sustainable delivery of radio frequency energy to the tissue consistent with complete, rapid, and uniform heating of the tissue.Type: ApplicationFiled: January 12, 2004Publication date: July 29, 2004Applicant: Scimed Life Systems, Inc.Inventors: Robert S. Behl, Eben L. Kermit, Peter F. Lyons, Colin J. Nichols
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Patent number: 6685700Abstract: Methods for heating tissue by delivering radio frequency energy through tissue electrodes comprise controlling energy delivery so that an abrupt increase in impedance between the electrodes and the tissue is observed, typically in the form of an abrupt decrease in power delivered to the electrodes. The power at which the impedance increases and/or the time required to induce such an increase in impedance, are relied on to determine acceptable ranges to achieve a maximum sustainable delivery of radio frequency energy to the tissue consistent with complete, rapid, and uniform heating of the tissue.Type: GrantFiled: November 13, 2001Date of Patent: February 3, 2004Assignee: RadioTherapeutics CorporationInventors: Robert S. Behl, Eben L. Kermit, Peter F. Lyons, Colin J. Nichols
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Patent number: 6379353Abstract: A probe system for volumetric tissue heating and ablation comprises a cannula having a multiple electrode component reciprocatably mounted therein. Individual electrodes within the array have spring memory so that they assume a radially outward, arcuate configuration as they are advanced distally from the cannula. Preferably, the electrodes fully evert as they are advanced from the cannula. Prior to deployment, the electrodes are constrained within a lumen of the cannula. The electrodes are maintained with a uniform circumferential spacing by confining them within an annular envelope defined by a core member within the cannula lumen, by providing electrodes having asymmetric cross-sectional geometries, and/or by nesting the electrodes closely together. Optionally, a cutting current may be applied to the electrodes as they are advanced.Type: GrantFiled: March 27, 2000Date of Patent: April 30, 2002Assignee: Radiotherapeutics CorporationInventor: Colin J. Nichols
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Publication number: 20020035362Abstract: Methods for heating tissue by delivering radio frequency energy through tissue electrodes comprise controlling energy delivery so that an abrupt increase in impedance between the electrodes and the tissue is observed, typically in the form of an abrupt decrease in power delivered to the electrodes. The power at which the impedance increases and/or the time required to induce such an increase in impedance, are relied on to determine acceptable ranges to achieve a maximum sustainable delivery of radio frequency energy to the tissue consistent with complete, rapid, and uniform heating of the tissue.Type: ApplicationFiled: November 13, 2001Publication date: March 21, 2002Applicant: RADIOTHERAPEUTICS CORPORATIONInventors: Robert S. Behl, Eben L. Kermit, Peter F. Lyon, Colin J. Nichols
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Patent number: 6358246Abstract: Methods for heating tissue by delivering radio frequency energy through tissue electrodes comprise controlling energy delivery so that an abrupt increase in impedance between the electrodes and the tissue is observed, typically in the form of an abrupt decrease in power delivered to the electrodes. The power at which the impedance increases and/or the time required to induce such an increase in impedance, are relied on to determine acceptable ranges to achieve a maximum sustainable delivery of radio frequency energy to the tissue consistent with complete, rapid, and uniform heating of the tissue.Type: GrantFiled: June 25, 1999Date of Patent: March 19, 2002Assignee: Radiotherapeutics CorporationInventors: Robert S. Behl, Eben L. Kermit, Peter F. Lyons, Colin J. Nichols
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Patent number: 6077261Abstract: Body lumens such as blood vessels are selectively occluded by mechanically collapsing the blood vessel and subsequently applying energy or other occlusive conditions within or adjacent the collapsed region. For example, vessel collapsing mechanisms can include spreadable opposed elements, reciprocating jaw mechanisms having penetrating elements, and devices for applying negative pressure to collapse the blood vessel. One or more electrodes can be used in a monopolar or bipolar fashion to apply radiofrequency or other energy to the body lumen in the region where it has been collapsed.Type: GrantFiled: December 31, 1997Date of Patent: June 20, 2000Assignee: Radiotherapeutics CorporationInventors: Robert S. Behl, Thomas Palermo, Colin J. Nichols
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Patent number: 6050992Abstract: A probe system for volumetric tissue heating and ablation comprises a cannula having a multiple electrode component reciprocatably mounted therein. Individual electrodes within the array have spring memory so that they assume a radially outward, arcuate configuration as they are advanced distally from the cannula. Preferably, the electrodes fully evert as they are advanced from the cannula. Prior to deployment, the electrodes are constrained within a lumen of the cannula. The electrodes are maintained with a uniform circumferential spacing by confining them within an annular envelope defined by a core member within the cannula lumen, by providing electrodes having asymmetric cross-sectional geometries, and/or by nesting the electrodes closely together. Optionally, a cutting current may be applied to the electrodes as they are advanced.Type: GrantFiled: May 19, 1997Date of Patent: April 18, 2000Assignee: Radiotherapeutics CorporationInventor: Colin J. Nichols
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Patent number: 5954717Abstract: Methods for heating tissue by delivering radio frequency energy through tissue electrodes comprise controlling energy delivery so that an abrupt increase in impedance between the electrodes and the tissue is observed, typically in the form of an abrupt decrease in power delivered to the electrodes. The power at which the impedance increases and/or the time required to induce such an increase in impedance, are relied on to determine acceptable ranges to achieve a maximum sustainable delivery of radio frequency energy to the tissue consistent with complete, rapid, and uniform heating of the tissue.Type: GrantFiled: September 25, 1997Date of Patent: September 21, 1999Assignee: Radiotherapeutics CorporationInventors: Robert S. Behl, Eben L. Kermit, Peter F. Lyons, Colin J. Nichols
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Patent number: 5709224Abstract: Body lumens such as blood vessels are selectively occluded by mechanically collapsing the blood vessel and subsequently applying energy or other occlusive conditions within or adjacent the collapsed region. For example, vessel collapsing mechanisms can include spreadable opposed elements, reciprocating jaw mechanisms having penetrating elements, and devices for applying negative pressure to collapse the blood vessel. One or more electrodes can be used in a monopolar or bipolar fashion to apply radiofrequency or other energy to the body lumen in the region where it has been collapsed.Type: GrantFiled: June 7, 1995Date of Patent: January 20, 1998Assignee: Radiotherapeutics CorporationInventors: Robert S. Behl, Thomas Palermo, Colin J. Nichols
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Patent number: 5542928Abstract: A thermal ablation catheter includes an elongate body member having a heating element disposed over a predetermined length of its distal end or within an axial lumen. The heating element is suspended away from an exterior surface of the elongate member to form a circulation region thereunder. Alternatively, the heating element is distributed over some or all of the axial lumen. Thermally conductive fluid can be introduced through the lumen in the elongate member and into the circulation region to effect heat transfer. The catheter is used to introduce the thermally conductive medium to a hollow body organ where the heating element raises the temperature of the medium sufficiently to induce injury to the lining of the organ. Optionally, an expandable cage in the catheter or on an associated introducer sheath may be used in combination with a thermal ablation catheter.Type: GrantFiled: June 27, 1994Date of Patent: August 6, 1996Assignee: InnerDyne, Inc.Inventors: Michael A. Evans, Colin J. Nichols, Laura Kemp, William R. Dubrul, Robert S. Behl
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Patent number: 5433708Abstract: A thermal ablation catheter includes an elongate body member having a heating element disposed over a predetermined length of its distal end. The heating element is suspended away from an exterior surface of the elongate member to form a circulation region thereunder. Thermally conductive fluid can be introduced through a lumen in the elongate member and distributed within the circulation region to improve heat transfer. The catheter is used to introduce the thermally conductive medium to a hollow body organ where the heating element raises the temperature of the medium sufficiently to induce injury to the lining of the organ. Optionally, an introducer sheath having an expandable cage at its distal end may be used in combination with a thermal ablation catheter. The expandable cage helps center the heating element on the catheter within the body organ and prevents direct contact between the heating element and the wall of the organ.Type: GrantFiled: June 7, 1993Date of Patent: July 18, 1995Assignee: Innerdyne, Inc.Inventors: Colin J. Nichols, William R. Dubrul, Robert S. Behl
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Patent number: 5250033Abstract: A peel-away introducer sheath includes a tube sheath having a splittable handle at its proximal end. A gas or liquid sealing valve or other fitting is secured to a proximal face of the handle and includes an axial passage typically having a diameter approximately equal to the lumen diameter of the sheath. The valve includes a threaded connector which is received in a counter bore formed in the handle. In this way, the sheath may be split apart leaving only the valve or other fitting in place on a catheter passing therethrough.Type: GrantFiled: October 28, 1992Date of Patent: October 5, 1993Assignee: Interventional Thermodynamics, Inc.Inventors: Michael A. Evans, Raymond S. Figueroa, Jr., Colin J. Nichols
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Patent number: 5188602Abstract: A catheter for thermally treating a hollow body organ includes a first flexible elongate member having a heater element at or near its distal end. A second flexible elongate member may be slidably disposed within a central lumen of the first flexible elongate member and may include an occluding means, such as an inflatable balloon, at its distal end. By first inserting the distal end of the second flexible elongate member within a hollow body organ or connecting region, the heater element on the first flexible elongate member may then be positioned and repositioned by axially translating the first flexible elongate member over the exterior of the second flexible elongate member. A collapsible shield may also be provided about the exposed heater element on the first flexible elongate member. The shield typically comprises a cylinder having a plurality of axial slots near its distal end.Type: GrantFiled: June 8, 1992Date of Patent: February 23, 1993Assignee: Interventional Thermodynamics, Inc.Inventor: Colin J. Nichols
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Patent number: 5160325Abstract: Catheter tubes of elastomeric material having novel lumen shapes which prevent occlusion and accommodate continued liquid flow even when kinked. Also, catheter tube slit valves are disclosed, the walls of which are not chemically weakened. Symmetrical and asymmetrical versions of said slit valves are disclosed. Combinations of highly reliable slit valves and catheter tubes are disclosed. Independently operable multi-lumen catheter assemblies of synthetic material, such as silicone rubber are disclosed, wherein the distal end of each lumen is normally closed by a three-position slit valve formed in a catheter tube covering.Type: GrantFiled: January 22, 1991Date of Patent: November 3, 1992Assignee: C. R. Bard, Inc.Inventors: Colin J. Nichols, Gregory N. Nordgren, Harvey R. Moorehead
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Patent number: 5100388Abstract: Hollow body organs, such as the gallbladder, may be ablated by introducing a substantially unheated thermally conductive medium to the interior of the organ. The thermally conductive medium is then heated to a temperature sufficient to necrose the endothelial lining or mucous membrane of the organ. After the lining or membrane has necrosed, the interior of the organ will fibrose over time and the organ will eventually be resorbed by the body. A catheter useful in performing the ablation method comprises an elongate member having a heating element at its distal tip. The catheter will include at least one lumen for delivering the thermally conductive medium to the interior of the hollow body organ, and the heating means is used to raise the temperature of the thermally conductive medium after it has been delivered.Type: GrantFiled: May 25, 1990Date of Patent: March 31, 1992Assignee: Interventional Thermodynamics, Inc.Inventors: Robert S. Behl, Colin J. Nichols
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Patent number: 4995863Abstract: Catheter tubes of elastomeric material having novel lumen shapes which prevent occlusion and accommodate continued liquid flow even when kinked. Also, catheter tube slit valves are disclosed, the walls of which are not chemically weakened. Symmetrical and asymmetrical versions of said slit valves are disclosed. Combinations of highly reliable slit valves and catheter tubes are disclosed. Independently operable multi-lumen catheter assemblies of synthetic material, such as silicone rubber are disclosed, wherein the distal end of each lumen is normally closed by a three-position slit valve formed in a catheter tube covering.Type: GrantFiled: February 25, 1988Date of Patent: February 26, 1991Assignee: Catheter Technology CorporationInventors: Colin J. Nichols, Gregory N. Nordgren, Harvey R. Moorehead
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Patent number: 4753640Abstract: Catheter tubes of elastomeric material having novel lumen shapes which prevent occlusion and accommodate continued liquid flow even when kinked. Also, catheter tube slit valves are disclosed, the walls of which are not chemically weakened. Symmetrical and asymmetrical versions of said slit valves are disclosed. Combinations of highly reliable slip valves and catheter tubes are disclosed. Independently operable multi-lumen catheter assemblies of synthetic material, such as silicone rubber are disclosed, wherein the distal end of each lumen is normally closed by a three-position slit valve formed in a catheter tube covering.Type: GrantFiled: October 6, 1986Date of Patent: June 28, 1988Assignee: Catheter Technology CorporationInventors: Colin J. Nichols, Gregory N. Nordgren, Harvey R. Moorehead
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Patent number: 4207988Abstract: Improvements in inner and outer closures for containers are disclosed. The outer closure is characterized by a cap member having a top wall, a side wall and a base adapted for sealing to the neck of a container. Two score lines extend across the top wall with finger gripping means attached at the apex where the two score lines meet. One score line extends down the side wall to connect with a third score line near the base which extends completely around the cap. The other score line extends down the side wall to an intermediate position and diverges away and terminates a short distance from the one score line. By pulling on the finger gripping means, the entire cap member above the third score line is removed in one piece. The inner closure comprises a plastic member sealed at its periphery to the mouth of the neck and includes a vertically aligned spike-entry port and an additive port which is oriented at an angle away from the entry port.Type: GrantFiled: May 18, 1979Date of Patent: June 17, 1980Assignee: Cutter Laboratories, Inc.Inventors: Myron R. Prouty, Colin J. Nichols, Norman A. Brown, Stephen P. Sutter
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Patent number: 4204604Abstract: An improvement in a closure system for containers in which a cap member sealed at its base to an annular flange about the neck of the container is removeable by a cutting ring. The cap includes an upwardly projecting brim at the base separated from the side wall of the cap to provide an annular groove. The groove has at least one tapered recess. The cutting ring which can be positioned around the side wall of the cap has at least one depending tab with an inwardly directed sharpened projection. Normally, the tab rests in the recess of the groove. Upon rotation of the cutting ring, the tab is forced inwardly causing the sharpened projection to sever the side wall of the closure.Type: GrantFiled: April 30, 1979Date of Patent: May 27, 1980Assignee: Cutter Laboratories, Inc.Inventors: Marius J. Morin, Colin J. Nichols, Myron R. Prouty