Patents by Inventor Colin James MCKINLAY

Colin James MCKINLAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multicomponent Delivery Systems for Polyanionic Cargo Compound Delivery
    Publication number: 20230293706
    Abstract: The present disclosure relates to multicomponent delivery systems for delivering polyanionic cargo compounds, such as nucleic acids. The present disclosure also relates to methods of preparing and using the multicomponent delivery systems.
    Type: Application
    Filed: August 6, 2021
    Publication date: September 21, 2023
    Inventor: Colin James McKinlay
  • Tertiary amino lipidated cationic peptides for nucleic acid delivery
    Patent number: 11701434
    Abstract: The present disclosure relates to tertiary amino lipidated and/or PEGylated cationic peptide compounds and complexes thereof with nucleic acids for endocellular delivery, methods for preparing the compounds and complexes, and methods for delivering polyanionic compounds to cells.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: July 18, 2023
    Assignee: NUTCRACKER THERAPEUTICS, INC.
    Inventor: Colin James McKinlay
  • LIPIDATED CATIONIC PEPTIDE-PEG COMPOSITIONS FOR NUCLEIC ACID DELIVERY
    Publication number: 20220323594
    Abstract: The present disclosure relates to complexes and compositions of cationic compounds combined with low mass percentages of PEGylated compounds, such as PEGylated lipids, for the delivery of nucleic acids and other polyanionic cargoes to cells, methods for preparing complexes and compositions comprising one or more cationic compounds and a low mass percentage of PEGylated compounds with polyanionic compounds, and methods for delivering the polyanionic compounds to cells.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 13, 2022
    Inventor: Colin James McKinlay
  • Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery
    Patent number: 11446394
    Abstract: The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: September 20, 2022
    Assignee: NUTCRACKER THERAPEUTICS, INC.
    Inventor: Colin James McKinlay
  • LIPID NANOPARTICLE FORMULATIONS COMPRISING LIPIDATED CATIONIC PEPTIDE COMPOUNDS FOR NUCLEIC ACID DELIVERY
    Publication number: 20210369867
    Abstract: The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 2, 2021
    Applicant: Nutcracker Therapeutics, Inc.
    Inventor: Colin James MCKINLAY
  • TERTIARY AMINO LIPIDATED CATIONIC PEPTIDES FOR NUCLEIC ACID DELIVERY
    Publication number: 20210371458
    Abstract: The present disclosure relates to tertiary amino lipidated and/or PEGylated cationic peptide compounds and complexes thereof with nucleic acids for endocellular delivery, methods for preparing the compounds and complexes, and methods for delivering polyanionic compounds to cells.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 2, 2021
    Applicant: Nutcracker Therapeutics, Inc.
    Inventor: Colin James MCKINLAY
  • TERTIARY AMINO LIPIDATED CATIONIC PEPTIDES FOR NUCLEIC ACID DELIVERY
    Publication number: 20210324002
    Abstract: The present disclosure relates to tertiary amino lipidated and/or PEGylated cationic peptide compounds and complexes thereof with nucleic acids for endocellular delivery, methods for preparing the compounds and complexes, and methods for delivering polyanionic compounds to cells.
    Type: Application
    Filed: September 27, 2019
    Publication date: October 21, 2021
    Applicant: Nutcracker Therapeutics, Inc.
    Inventor: Colin James MCKINLAY
  • LIPID NANOPARTICLE FORMULATIONS COMPRISING LIPIDATED CATIONIC PEPTIDE COMPOUNDS FOR NUCLEIC ACID DELIVERY
    Publication number: 20210322575
    Abstract: The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.
    Type: Application
    Filed: September 27, 2019
    Publication date: October 21, 2021
    Applicant: Nutcracker Therapeutics, Inc.
    Inventor: Colin James MCKINLAY