Abstract: An annular seal for chromatography columns adapted for radial sealing with an inner cylindrical surface, having a compressive surface disposed on the inner annular edge of the seal, and a sealing surface disposed on the outer annular edge of the seal, whereas the sealing face is substantially planar and has two parallel edges, which sealing face further comprises at least one release ridge disposed on the sealing surface adjacent to each parallel edge, which release ridge aids in ensuring breaking of the seal between the sealing face and the inner cylindrical surface.

Abstract: An end cell for a chromatography column has a moulded plastics structure and an integral screen formed of a woven mesh of fibres of the same plastic material as used for the end cell. A peripheral ring of the same plastics material is injection moulded to the perimeter of the mesh, said ring being secured to the end cell in a leak-proof manner, preferably by ultrasonic welding.