Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain in complex with human insulin and to methods of using the crystal and related structural information to identify, design and screen for compounds that interact with or modulate the insulin receptor and insulin receptor signalling.

Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR ?-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.

Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.

Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR ?-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.

Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.

Abstract: The invention provides a filter for separating very small particles or organisms from the air or gas in which they are carried, comprising a filter mechanism and a duct, chamber or pipe to contain and transport the air or gas and to house the filter mechanism; the filter mechanism comprising: a particle charging means, a means to introduce charged or uncharged atomized droplets of liquids or reagents into the air or gas after the particle charging stage, and a capture means for collecting the atomized droplets and/or very small particles or organisms.

Abstract: To provide a globally useful telephone number a character string which may be similar to an email address may be provided to a mobile phone server or an internet server for translation to the actual phone number and establishment of a call to that number.

Abstract: A foundation component (1) is disclosed which is suitable for forming part of a modular foundation for a building structure. The foundation component (1), defines at least one receptacle (2) which, in use, may be filled with a suitable particulate material. A plurality of protrusions (5) extending generally downwards from the base (6) of the foundation component (1) engage a foundation surface on which the foundation component is located. In a preferred embodiment the foundation component may include tongue in groove interengagement of adjacent foundation components (1), and may also include provision for service channels and reinforcing rods.

Abstract: The present invention is a system and method combining financial product innovation, business process management, and proprietary software integration in a holistic fashion for the funding, trading, processing and management of commercial accounts receivable.