Patents by Inventor Colin Loweth

Colin Loweth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrrolo[2,3-B]pyridines as MLK inhibitors
    Patent number: 8877772
    Abstract: Provided are compounds having an inhibitory effect on Mixed Lineage Kinases, having a structural Formula, Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: November 4, 2014
    Assignee: University of Rochester
    Inventors: Harris A. Gelbard, Stephen Dewhurst, Val S. Goodfellow, Colin Loweth, Torsten Wiemann
  • Thiazole and thiadiazole inhibitors of tyrosine phosphatases
    Publication number: 20060194768
    Abstract: Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.
    Type: Application
    Filed: September 2, 2005
    Publication date: August 31, 2006
    Inventors: Zacharia Cheruvallath, Colin Loweth, Ruth Nutt, Darryl Rideout, Joseph Semple, Jing Wang, Feiyue Wu, Shankari Mylvaganam, Hengyi Zhu, Jianzhong Sun
  • Trisubstituted nitrogen modulators of tyrosine phosphatases
    Publication number: 20060135773
    Abstract: Compounds, compositions and methods are provided for modulating the activity of protein tyrosine phosphatases, including PTP-1B. In one embodiment, the compounds are N,N-dibenzylarylsulfonamides.
    Type: Application
    Filed: June 17, 2005
    Publication date: June 22, 2006
    Inventors: Joseph Semple, Darryl Rideout, Ruth Nutt, Mark Shenderovich, Jing Wang, Shankari Mylvaganam, Feiyue Wu, Chung Tsai, Venkatachalapathi Yalamoori, Colin Loweth
  • Organosulfur inhibitors of tyrosine phosphatases
    Publication number: 20050065118
    Abstract: Organosulfur modulators of tyrosine phosphatases and their use in the treatment of disease are disclosed.
    Type: Application
    Filed: October 16, 2002
    Publication date: March 24, 2005
    Inventors: Jing Wang, Darryl Rideout, Kalyanaraman Ramnarayan, Chung-Ying Tsai, Venkatachalapathi Yalamoori, Feiyue Wu, Colin Loweth, Hassan ElAbdellaoui, Leah Fung, Thomas Brady