Abstract: A steering wheel actuation device, for example in ADAS testing, is provided. The actuation device can include a steering wheel actuator to selectively move during testing between an engaged configuration and a disengaged configuration. The actuation device can impart an actuation force to a vehicle steering wheel in the engaged configuration, and can vary the magnitude of the resistance it creates to the turning of the steering wheel during testing.

Abstract: A target vehicle, for example a two-wheeled vehicle, for mounting onto an ADAS (Advanced Driver Assistance System) testing platform is provided. The target vehicle comprises one or more sensors and an actuation assembly comprising an actuator. The sensors are arranged to measure a parameter relating to the dynamics of the target vehicle and may for example comprise accelerometers. The actuation assembly adjusts the tilt of the target vehicle in dependence on the output of the sensor(s), for example by means of a control unit. The tilting of the vehicle during cornering may thus be simulated. The measuring of such a parameter and the adjusting of the tilt may be conducted remotely from the testing platform. The sensor(s), control unit and actuator assembly may be self-contained within the target vehicle. A method of modeling a VRU (Vulnerable Road User) for ADAS testing is also provided.

Abstract: An anti-lock sensor ring may have a flattened exciting portion having a retention mechanism projecting from a ring radial edge. The retention mechanism may have cantilever spring retention clips elastically deformable to snap on a disc brake band retention seat. The mechanism may also have a cantilever support portion disposed side by side to and spaced apart from the cantilever spring retention clips. Each of the cantilever spring retention clips may have a retention surface and the cantilever support portion with a support surface. When the anti-lock sensor ring is dismounted from a disc brake band, the plane defined by the retention surface and the plane defined by the support surface are facing each other in order to create opposing gripping elements.

Abstract: Provided herein are immunoconjugates comprising an anti-ROR1 antibody or an antigen-binding fragment thereof and an exatecan moiety or an analog thereof. These immunoconjugates are useful for treating ROR1-expressing cancers.

Abstract: A braking band of a disk brake disk has a first plate and a second plate arranged joined to each other by connecting elements. The first and second plates have first and second plate outer surfaces, opposite portions of the first and second outer surfaces forming opposite braking surfaces. The braking band has a plurality of attachment portions for connecting the braking band to a vehicle hub or a bell. Each attachment portion has a connection seat. The attachment portions are spaced by recesses. Each attachment portion has an attachment portion wall having opposite side wall portions, two bottom wall portions and an inner end wall portion, and opposite first and second attachment portion surfaces. Each recess extends radially beyond the connection seat. Each side wall portion is joined to the adjoining bottom wall portion by a cylindrical bottom arch avoiding edges. Each side wall portion is joined to the adjoining inner end wall portion by a cylindrical end arch avoiding edges.

Abstract: An anti-lock sensor ring may have a flattened exciting portion having a retention mechanism projecting from a ring radial edge. The retention mechanism may have cantilever spring retention clips elastically deformable to snap on a disc brake band retention seat. The mechanism may also have a cantilever support portion disposed side by side to and spaced apart from the cantilever spring retention clips. Each of the cantilever spring retention clips may have a retention surface and the cantilever support portion with a support surface. When the anti-lock sensor ring is dismounted from a disc brake band, the plane defined by the retention surface and the plane defined by the support surface are facing each other in order to create opposing gripping elements.

Abstract: A robot has brake and accelerator actuating levers (9, 10) and a rotary actuator (12) between them. A drive ring (16) is fast with an actuator drive member (14) and between them they captivate a journal bearing (17) for the brake actuating lever (9) on which a return spring (19) acts. Advance of the lever is via a cam member (31) adjacent it. Wherever the output drive member (14) from the rotary actuator is turned, the cam member is rotated correspondingly. For brake application, the drive member (14) is driven, clockwise in FIG. 2. For brake release, and accelerator application, the drive member is driven back and the cam member is disengaged from the lever (9) with unidirectional freedom. The drive ring (16) is carried on a central ‘clutch’ member (35). The central member (35) is journalled in a fixed clutch member (36), which carries a clutch operating winding (38) for clutching together the central member (35) and an accelerator drive member (39) journalled on the central member.

Abstract: Described herein are chimeric polypeptides that include one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Additional aspects of the present disclosure provide genetically altered plants having a chimeric polypeptide including one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Further aspects of the present disclosure relate to genetically altered plants having a stabilized polypeptide including two or more RBMs and one or both of an algal Rubisco-binding membrane protein (RBMP) and a Rubisco small subunit (SSU) protein. Other aspects of the present disclosure relate to methods of making such chimeric polypeptides and plants, as well as cultivating these genetically altered plants.

Abstract: A braking band of a disk brake disk has a first plate and a second plate arranged joined to each other by connecting elements. The first and second plates have first and second plate outer surfaces, opposite portions of the first and second outer surfaces forming opposite braking surfaces. The braking band has a plurality of attachment portions for connecting the braking band to a vehicle hub or a bell. Each attachment portion has a connection seat. The attachment portions are spaced by recesses. Each attachment portion has an attachment portion wall having opposite side wall portions, two bottom wall portions and an inner end wall portion, and opposite first and second attachment portion surfaces. Each recess extends radially beyond the connection seat. Each side wall portion is joined to the adjoining bottom wall portion by a cylindrical bottom arch avoiding edges. Each side wall portion is joined to the adjoining inner end wall portion by a cylindrical end arch avoiding edges.

Abstract: A target vehicle, for example a two-wheeled vehicle, for mounting onto an ADAS (Advanced Driver Assistance System) testing platform is provided. The target vehicle comprises one or more sensors and an actuation assembly comprising an actuator. The sensors are arranged to measure a parameter relating to the dynamics of the target vehicle and may for example comprise accelerometers. The actuation assembly adjusts the tilt of the target vehicle in dependence on the output of the sensor(s), for example by means of a control unit. The tilting of the vehicle during cornering may thus be simulated. The measuring of such a parameter and the adjusting of the tilt may be conducted remotely from the testing platform. The sensor(s), control unit and actuator assembly may be self-contained within the target vehicle. A method of modeling a VRU (Vulnerable Road User) for ADAS testing is also provided.

Abstract: A robot has brake and accelerator actuating levers (9, 10) and a rotary actuator (12) between them. A drive ring (16) is fast with an actuator drive member (14) and between them they captivate a journal bearing (17) for the brake actuating lever (9) on which a return spring (19) acts. Advance of the lever is via a cam member (31) adjacent it. Wherever the output drive member (14) from the rotary actuator is turned, the cam member is rotated correspondingly. For brake application, the drive member (14) is driven, clockwise in FIG. 2. For brake release, and accelerator application, the drive member is driven back and the cam member is disengaged from the lever (9) with unidirectional freedom. The drive ring (16) is carried on a central ‘clutch’ member (35). The central member (35) is journalled in a fixed clutch member (36), which carries a clutch operating winding (38) for clutching together the central member (35) and an accelerator drive member (39) journalled on the central member.

Abstract: Disclosed is a solid phase method of synthesising biomolecule-effector-conjugates and biomolecule-reporter-conjugates. In particular, this invention relates to a solid phase method of synthesising antibody-effector-conjugates and antibody-reporter conjugates. This invention also relates to intermediate methods of producing immobilised, chemically modified biomolecules, e.g., antibodies.

Abstract: Disclosed is a solid phase method of synthesizing biomolecule-drug-conjugates. In particular, this invention relates to a solid phase method of synthesizing antibody-drug-conjugates (ADCs). This invention also relates to intermediate methods of producing immobilized, chemically modified biomolecules, e.g., antibodies.

Abstract: Disclosed is a solid phase method of synthesising biomolecule-drug-conjugates (e.g. antibody-drug-conjugates) using photocleavable moieties. The method comprises: (i) providing an immobilised photocleavable group-biomolecule conjugate; (ii) optionally contacting the immobilised photocleavable group-biomolecule conjugate with a chemical modification agent or activating agent to provide an immobilised photocleavable group-biomolecule conjugate that is chemically modified or activated at the biomolecule portion; (iii) contacting the immobilised photocleavable group-biomolecule conjugate of step (i) or the chemically modified or activated immobilised photocleavable group-biomolecule conjugate of step (ii) with a drug component to form an immobilised photocleavable group-biomolecule-drug-conjugate; and (iv) irradiating the immobilised photocleavable group-biomolecule-drug-conjugate of step (iii) with radiation thereby releasing the biomolecule-drug-conjugate.

Abstract: Glasses storage system. In one example embodiment, a glasses storage system includes a frame configured to position one or more lenses in front of one or both eyes of a user and an earpiece configured to support the frame. The earpiece surrounds a hollow storage cavity that is defined internally to the earpiece.

Abstract: Glasses storage system. In one example embodiment, a glasses storage system includes a frame configured to position one or more lenses in front of one or both eyes of a user and an earpiece configured to support the frame. The earpiece surrounds a hollow storage cavity that is defined internally to the earpiece.

Abstract: A system for storing small items. The system includes a glasses frame. The system also includes an earpiece, where the earpiece includes a hollow cavity.

Abstract: A system for storing small items. The system includes a glasses frame. The system also includes an earpiece, where the earpiece includes a hollow cavity.

Abstract: The invention relates to the X-ray crystal structure of PfA-M1 aminopeptidase alone, and in complex with the phosphinate dipeptide analogue hPheP[CH2]Phe. More specifically the present invention provides the structure coordinates of PfA-M1 and PfA-M1 in complex with Co4. The invention also includes the use of the X-ray crystal structures as drug target models for anti-malarial drug design and a method for identifying or designing novel anti-malarial drugs, for example using high-throughput chemical screening and medicinal chemistry methods. The invention further provides anti-malarial drugs identified or designed according to the aforementioned method and their use for obstructing protein metabolism and synthesis in a parasite by blocking the entrance of Hb-derived peptides and/or blocking the exit of released amino acids at the active site of PfA-M1 protease.