Abstract: Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis.

Abstract: Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis.

Abstract: A method for controlling game play for use in a video game, wherein a plurality of possible animated actions can be taken by a game character in response to an input from a user provided through a game controller. The method includes: detecting user input from the game controller requesting an animated action by the player; reading an adrenaline value from a control element on the controller indicating a level of aggression desired by the user for the animated action; selecting an animated action from the plurality of possible animated actions based at least in part on the adrenaline value; and performing the selected animated action.

Abstract: An improved passing feature for sports videogames that enables passing of, for example, a virtual ball, in a direction that is different than the direction in which the virtual player is moving on the virtual playing field. In accordance with the instant invention, the moving direction for a virtual player and the passing direction for that player are made independent, thereby providing more fluid passing and greatly enhancing gameplay. The passing feature can be implemented on a game controller having one or two analog joysticks.

Abstract: A method for controlling game play for use in a video game, wherein a plurality of possible animated actions can be taken by a game character in response to an input from a user provided through a game controller. The method includes: detecting user input from the game controller requesting an animated action by the player; reading an adrenaline value from a control element on the controller indicating a level of aggression desired by the user for the animated action; selecting an animated action from the plurality of possible animated actions based at least in part on the adrenaline value; and performing the selected animated action.