Patents by Inventor Colin R. Tuohey
Colin R. Tuohey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10442674Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.Type: GrantFiled: July 29, 2016Date of Patent: October 15, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin R. Tuohey, Thomas Erdenberger, Richard L. Damren, Kenneth Clapp, Parrish M. Galliher, Jonathan Kenney
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Publication number: 20190078046Abstract: A bioreactor system and packaging is provided. The bioreactor system includes a vessel for housing biomaterials for processing and a support structure. The vessel includes a flexible material defining a chamber and a mixing system positioned within the chamber. The mixing system includes an agitator for imparting motion and mixing to the contents of the vessel and includes a base affixed to the flexible material at a base section of the chamber, a shaft moveably mounted in the base and extending from the base into the chamber and at least one mixing element mounted to the shaft, the shaft configured to be driven by a motor magnetically coupled to the shaft and external to the lower portion of the chamber. The support structure is connected to the mixing system such that the shaft is moveable therein and configured to cooperate with an external structure to provide support for the shaft.Type: ApplicationFiled: October 11, 2016Publication date: March 14, 2019Applicant: GE Healthcare Bio-Sciences Corp.Inventors: Steven James Forsberg, Ralph Stankowski, Colin R. Tuohey
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Publication number: 20180143042Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.Type: ApplicationFiled: January 3, 2018Publication date: May 24, 2018Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: RICHARD L. DAMREN, COLIN R. TUOHEY, THOMAS ERDENBERGER, MICHAEL FISHER, JONATHAN A. KENNEY, PARRISH M. GALLIHER, JOSEPH D. CROWELL
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Publication number: 20180126344Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: ApplicationFiled: April 11, 2016Publication date: May 10, 2018Inventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
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Publication number: 20180119084Abstract: The invention discloses a bioreactor apparatus (1;101;201;301) for cultivation of cells comprising: a) a disposable bioreactor vessel (2) with one or more walls (3,4,5) defining an inner volume (6), at least one port (10) in a wall, wherein the disposable bioreactor vessel is positioned in a rigid support structure (8;108); and b) a heater (9;109;209;309), capable of heating an amount of culture medium to a target temperature in the range of 55-95° C., while the amount of culture medium is being confined in or conveyed to the inner volume.Type: ApplicationFiled: April 12, 2016Publication date: May 3, 2018Inventors: Colin R. Tuohey, Richard Lee Damren, Thomas John Erdenberger, Parish M. Galliher, Patrick M. Guertin
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Patent number: 9891080Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.Type: GrantFiled: October 28, 2012Date of Patent: February 13, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
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Publication number: 20180015189Abstract: The invention discloses a method for virus clearance of a cell culture medium, comprising the steps of: i) providing a bulk medium portion, comprising amino acids and glucose, and a first additive portion, comprising vitamins in aqueous solution; ii) subjecting the bulk medium portion to a high temperature short time treatment (HTST); iii) passing the first additive portion through a virus retentive filter or an ultrafilter; and iv) after steps ii) and iii), mixing the bulk medium portion with the first additive portion to obtain a cell culture medium.Type: ApplicationFiled: September 28, 2017Publication date: January 18, 2018Inventors: Andreas Castan, Colin R. Tuohey
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Publication number: 20170362555Abstract: A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.Type: ApplicationFiled: December 22, 2015Publication date: December 21, 2017Inventors: Richard Lee Damren, Colin R. Tuohey
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Publication number: 20170107471Abstract: A bioreactor system and packaging is provided. The bioreactor system includes a vessel for housing biomaterials for processing and a support structure. The vessel includes a flexible material defining a chamber and a mixing system positioned within the chamber. The mixing system includes an agitator for imparting motion and mixing to the contents of the vessel and includes a base affixed to the flexible material at a base section of the chamber, a shaft moveably mounted in the base and extending from the base into the chamber and at least one mixing element mounted to the shaft, the shaft configured to be driven by a motor magnetically coupled to the shaft and external to the lower portion of the chamber. The support structure is connected to the mixing system such that the shaft is moveable therein and configured to cooperate with an external structure to provide support for the shaft.Type: ApplicationFiled: October 16, 2015Publication date: April 20, 2017Inventors: Steven James FORSBERG, Ralph STANKOWSKI, Colin R. TUOHEY
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Publication number: 20170051246Abstract: Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.Type: ApplicationFiled: November 8, 2016Publication date: February 23, 2017Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: PARRISH M. GALLIHER, THOMAS ERDENBERGER, COLIN R. TUOHEY, JOSEPH D. CROWELL, RICHARD L. DAMREN
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Patent number: 9550157Abstract: Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are “receiver-less” retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.Type: GrantFiled: September 13, 2012Date of Patent: January 24, 2017Assignee: GE HEATHCARE BIO-SCIENCES CORPInventors: Thomas Erdenberger, Richard L. Damren, Colin R. Tuohey, Michael Fisher, Parrish M. Galliher, Jonathan A. Kenney
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Publication number: 20170008752Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.Type: ApplicationFiled: July 29, 2016Publication date: January 12, 2017Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: COLIN R. TUOHEY, THOMAS ERDENBERGER, RICHARD L. DAMREN, KENNETH CLAPP, PARRISH M. GALLIHER, JONATHAN KENNEY
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Patent number: 9534196Abstract: Disclosed is a heat exchange module for use in a chemical, pharmaceutical or biological reactor system, the module configured to be disposed in the reactor system having a flexible single use container, and including at least one thermally conductive surface adapted to contact the flexible single use container to facilitate heat transfer, and a fluid circulation path through which a heat exchange fluid can be circulated.Type: GrantFiled: January 14, 2013Date of Patent: January 3, 2017Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Parrish M. Galliher, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Richard L. Damren
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Patent number: 9475686Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.Type: GrantFiled: March 7, 2013Date of Patent: October 25, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin R. Tuohey, Thomas Erdenberger, Richard L. Damren, Kenneth Clapp, Parrish M. Galliher, Jonathan Kenney
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Publication number: 20160230138Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.Type: ApplicationFiled: April 14, 2016Publication date: August 11, 2016Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: RICHARD L. DAMREN, THOMAS ERDENBERGER, COLIN R. TUOHEY, JOSEPH D. CROWELL, PARRISH M. GALLIHER, KENNETH P. CLAPP, PETER A. MITCHELL
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Patent number: 9340763Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system can include a body configured to be disposed in the reactor system having an inner replaceable reactant container is disclosed. The body can further include at least one thermally conductive surface adapted to contact the inner replaceable reactant container to facilitate heat transfer. Furthermore, the heat exchange module can include a heat exchanger disposed within the module body and can include a fluid circulation path through which a heat exchange fluid can be circulated.Type: GrantFiled: December 3, 2012Date of Patent: May 17, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard L. Damren, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Parrish M. Galliher, Kenneth P. Clapp, Peter A. Mitchell
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Publication number: 20150299641Abstract: Disclosed is a heat exchange module for use in a chemical, pharmaceutical or biological reactor system, the module configured to be disposed in the reactor system having a flexible single use container, and including at least one thermally conductive surface adapted to contact the flexible single use container to facilitate heat transfer, and a fluid circulation path through which a heat exchange fluid can be circulated.Type: ApplicationFiled: January 14, 2013Publication date: October 22, 2015Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: PARRISH M. GALLIHER, THOMAS ERDENBERGER, COLIN R. TUOHEY, JOSEPH D. CROWELL, RICHARD L. DAMREN
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Patent number: 9127242Abstract: A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.Type: GrantFiled: April 5, 2010Date of Patent: September 8, 2015Inventors: Patrick M. Guertin, Parrish M. Galliher, Michael Fisher, Joseph D. Crowell, Colin R. Tuohey, Laura A. Niklason, William E. Tente, Shannon M. Dahl, Juliana Blum, Justin Strader
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Patent number: 9080983Abstract: Disclosed is a sensor and housing assembly for a single-use bioreactor system, including a device for operatively associating a sensor with a flexible wall, the device comprising an internal housing portion that is removable and variably positionable on an internal surface of the flexible wall, the internal housing portion comprising a chemical detector sensor, which may be an optical chemical detector sensor.Type: GrantFiled: January 28, 2013Date of Patent: July 14, 2015Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Parrish M. Galliher, Thomas Erdenberger, Colin R. Tuohey, Richard L. Damren
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Patent number: D768740Type: GrantFiled: April 17, 2015Date of Patent: October 11, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney