Abstract: This invention relates to the therapeutic and prophylactic use of a combination including lactoperoxidase and at least one other component, with an isoelectric point of, or substantially above 6.8, and which are extracted from milk, to modulate the microbiome of an animal by selectively against at least one pathogenic microoganism.

Abstract: AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.

Abstract: The present invention relates to products and processes for the treatment or prevention of viral infection(s). In particular the invention relates to the use of one or more proteins, typically obtained from milk, for the treatment or prevention of viral infection(s). In particular embodiments the invention uses combinations of milk proteins for the treatment or prevention of viral infection(s). The products of the invention may be used in combination with other active agents, including other antiviral agents.

Abstract: AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.

Abstract: A system for detecting rotational over travel includes: an angular position sensor comprising a rotor rotatable about an axis, the angular position sensor configured to output one or more electrical signals to indicate an angular position of the rotor about the axis and/or a number of turns completed by the rotor about the axis; and a device comprising a first operating mode and a second operating mode and configured to transition from the first operating mode to the second operating mode in response to the rotor rotating beyond at least one angular position threshold, wherein the transition from the first operating mode to the second operating mode is independent of the one or more electrical signals.

Abstract: A system for controlling a hydraulic component. The system includes a control system configured to carry out a health check routine having steps of (A) fluidly connecting one of the hydraulic supply systems with the component until (i) a predetermined pressure is reached on the hydraulic supply side and/or the hydraulic return side, and/or (ii) a predetermined amount of time has passed; then (B) isolating the pressurised hydraulic fluid within the hydraulic supply side and the hydraulic return side so that hydraulic fluid leaks from the hydraulic supply side to the hydraulic return side via the controlled leakage; (C) monitoring the pressure of hydraulic fluid within the hydraulic supply side (50S) and/or the hydraulic return side over time; and then (D) determining if the pressure of hydraulic fluid within the hydraulic supply side and/or the hydraulic return side follows a predetermined or expected pattern.

Abstract: AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.

Abstract: This invention relates to the therapeutic and prophylactic use of a combination including lactoperoxidase and at least one other component, with an isoelectric point of, or substantially above 6.8, and which are extracted from milk, to modulate the microbiome of an animal by selectively against at least one pathogenic microoganism.

Abstract: Known security systems issue an audible and/or visible alarm to alert all those local to a secured article that the article has been compromised. However, for various reasons, passers-by do not respond to such an alarm/alert. According to the present invention, if an intruder interferes with a secured article, a sensor may detect an event associated with an article being interfered with and/or compromised. This detection will trigger (via a processor) an alarm condition, and a transceiver will send an alarm signal to a monitoring device over a communication network; however, no indication of the alarm condition is detectable outside the housing by means other than via the alarm signal. In this way, an intruder compromising an article is not alerted to detection of the event by the sensor. Therefore, authorities may be summoned to apprehend the intruder without the intruder being provided with the opportunity to escape.

Abstract: Known security systems issue an audible and/or visible alarm to alert all those local to a secured article that the article has been compromised. However, for various reasons, passers-by do not respond to such an alarm/alert. According to the present invention, if an intruder interferes with a secured article, a sensor may detect an event associated with an article being interfered with and/or compromised. This detection will trigger (via a processor) an alarm condition, and a transceiver will send an alarm signal to a monitoring device over a communication network; however, no indication of the alarm condition is detectable outside the housing by means other than via the alarm signal. In this way, an intruder compromising an article is not alerted to detection of the event by the sensor. Therefore, authorities may be summoned to apprehend the intruder without the intruder being provided with the opportunity to escape.

Abstract: A novel single domain antibody AFAI and fragments thereof which has specific affinity for binding to carcinoma, and especially lung carcinoma. This antibody, and portions thereof, can be used, inter alia in the diagnosis and treatment of carcinoma.

Abstract: Disclosed herein are lung cancer specific binding agents, as well as related amino acid and nucleic acid sequences. Methods of using such agents in the diagnosis and treatment of treat lung cancer are also disclosed. In an embodiment of the invention there is provided an antibody or fragment thereof comprising the sequence Ser Gly Asn Gly Gly Thr in the region corresponding to the CDR 2.

Abstract: A device suitable for use as an intra vaginal device or as a bolus where, after initiation, a member (usually a plunger) moves with a known movement characteristic and is involved in the stagger release of multiple materials. That moving member is used to time the discharge of one or more material from its reservoir in the device (there being separate powering of the timed discharge) or is used to both time and indirectly power the discharge of one or more material from its reservoir, such discharges preferably being in a staggered manner. Optionally the moving member as a plunger may itself also directly discharge a material from a reservoir.

Abstract: A passive or active release device for a medicament or other substance for a target species mammal. The device is of a kind capable of being inserted into a body cavity of a target species mammal and deploying resiliently to one or more retention condition(s). The device is wholly or in part moulded from poly (-caprolactone) (optionally impregnated with at least a physiologically effective agent to be released therefrom or optionally to carry some device or material to be body cavity retained at least for a period). The device is preferably of substantially a “T” or “Y” shape.

Abstract: The present invention relates to the soakable crystal structures of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. The present invention additionally relates to crystals of PDE5 into which ligands may be soaked and crystals of PDE5 comprising PDE5 ligands that have been soaked into the crystal.