Abstract: The present invention relates to prostate cancer (PC), in particular the identification of certain bacteria in prostate cancer tissues or liquid biopsies and the use of such identification as a prognostic indicator of cancer progression. The present invention also relates to cultures of newly identified bacteria and means for identifying such bacteria in biological samples.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.

Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: Disclosed is a method of phonetically encoding a text document. The method comprises providing, for a current word in the text document, a phonetically equivalent encoded word comprising one or more syllables, each syllable comprising a sequence of phonemes from a predetermined phoneme set, the sequence being phonetically equivalent to the corresponding syllable in the current word, and adding the phonetically equivalent encoded word or the current word at a current position in the phonetically encoded document, Each phoneme in the phoneme set is associated with a base grapheme that is pronounced as the phoneme in one or more English words.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: The present invention relates to biomarkers and diagnostic profiles based on the expression status of particular genes for use in the diagnosis of prostate cancer, in particular the early detection of prostate cancer and prediction of disease progression and Gleason ?4 cancer. The present invention also provides methods of diagnosis and treatment of prostate cancer, and kits for the early detection of prostate cancer based on the expression status of the biomarkers in biological samples, in particular urine samples.

Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.

Abstract: Disclosed is a method of phonetically encoding a text document. The method comprises providing, for a current word in the text document, a phonetically equivalent encoded word comprising one or more syllables, each syllable comprising a sequence of phonemes from a predetermined phoneme set, the sequence being phonetically equivalent to the corresponding syllable in the current word, and adding the phonetically equivalent encoded word or the current word at a current position in the phonetically encoded document, Each phoneme in the phoneme set is associated with a base grapheme that is pronounced as the phoneme in one or more English words.

Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.

Abstract: Disclosed is a method of phonetically encoding a text document. The method comprises providing, for a current word in the text document, a phonetically equivalent encoded word comprising one or more syllables, each syllable comprising a sequence of phonemes from a predetermined phoneme set, the sequence being phonetically equivalent to the corresponding syllable in the current word, and adding the phonetically equivalent encoded word or the current word at a current position in the phonetically encoded document. Each phoneme in the phoneme set is associated with a base grapheme that is pronounced as the phoneme in one or more English words.

Abstract: Systems, methods, and software can be used to generate predictive text on an electronic device. In some aspects, one computer-implemented method includes receiving, at an input method editor (IME) operating on an electronic device, a text prediction indicator for an editable field outputted by an application; determining, based on the text prediction indicator, whether a text input from the editable field is allowed to be stored; in response to determining that the text input from the editable field is allowed to be stored, storing the text input; determining a predictive text; and outputting the predictive text on the electronic device.

Abstract: A teaching system for teaching a user, the teaching system comprising a learning interface module (112), a user classification module (116) and a learning activity control module (114, 122), wherein: the learning interface module (112) is arranged to receive user information associated with a user and store the user information in a user information database (115); the user classification module (116) is arranged to obtain a user classification code based on the user information and store the user classification code in a learning outcome database (117), and the learning activity control module (114, 122) is arranged to select at least one learning activity from a learning activity database (118) based on the user classification code and communicate the selected learning activity to the learning interface module (112) for reception by the user.

Abstract: Systems and methods are disclosed for producing documents in a specialized format adapted to aid readability, such as word-recognition and word-processing capabilities. Marked-up documents stored in a repository are created by marking up previously unmarked-up documents according to one or more schemas, to include explicit structural information that corresponds to implicit structural information originally contained in the unmarked-up documents. A user may request a specially formatted document by selecting one of a number of available stored document formats including formatting rules or parameters to be applied to a selected one of the marked-up documents.

Abstract: A medical procedure localization aid produces reference marks on both the patient and the medical imaging scan. The aid is defined by an imaging substrate having indicia on one side that is opaque to medical imaging and a second substrate having indicia that appears on the patient's surface for the procedure. Anchor points align the second substrate to the same position as the first substrate on the patient. By visualizing the location of a target on the scan image relative to the indicia on the scan image and comparing that with indicia on the patient, a medical processional may reliably locate where a medical procedure should be performed.

Abstract: An electronic device for text prediction in a virtual keyboard. The device includes a memory including an input determination module for execution by the microprocessor, the input determination module being configured to: receive signals representing input at the virtual keyboard, the virtual keyboard being divided into a plurality of subregions, the plurality of subregions including at least one subregion being associated with two or more characters and/or symbols of the virtual keyboard; identify a subregion on the virtual keyboard corresponding to the input; determine any character or symbol associated with the identified subregion; and if there is at least one determined character or symbol, provide the at least one determined character or symbol to a text prediction algorithm.