Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.

Abstract: Techniques regarding determining hyperparameters for a differentially private federated learning process are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a hyperparameter advisor component that determines a hyperparameter for a model of a differentially private federated learning process based on a defined numeric relationship between a privacy budget, a learning rate schedule, and a batch size.

Abstract: A mobile device mounting system includes a device case and a mount. The device case includes: an insert including a rectangular bore and defining a set of undercut sections about the rectangular bore; and a first set of magnetic elements arranged in a first pattern about the rectangular bore. The mount includes: a body; a polygonal boss extending from the body and configured to insert into the rectangular bore; a set of locking jaws arranged on the polygonal boss configured to transiently mate with the set of undercut sections to constrain the polygonal boss within the rectangular bore; and a second set of magnetic elements arranged in a second pattern about the polygonal boss and configured to transiently couple to the first set of magnetic elements to transiently retain the mount against the device case and to drive the set of locking jaws toward the set of undercut sections.

Abstract: Systems and methods to implement customer contact service with real-time supervisor assistance. A supervisor may oversee multiple agents in a customer contact service. A service of a computing resource service provider may monitor a plurality of audio connections at a service of a computing resource service provider, generate transcripts for the plurality of audio data, analyze the transcripts using a set of natural language processing (NLP) techniques to generate metadata, tag the transcripts with categories based at least in prat on the metadata, generate information for at least a portion of the plurality of connections based on the transcripts, metadata, and categories, and provide the information to a supervisor of the agents.

Abstract: A data compression system can include a neural compression artifact removal module (NCARM) is arranged to receive compressible data and output data with compression artifacts removed. A lossy compression module can be arranged to at least one of receive and send data to the NCARM and a decompression module arranged to at least one of receive and send data to the NCARM. In some embodiments, the NCARM sends data to the lossy compression module. Alternatively, the NCARM can receive data from the decompression module and/or data from the lossy compression module. Many lossy data compression schemes, including commonly available audio and video compression methods, can benefit from artifact removal.

Abstract: A system includes a memory and a queue manager that maintains a virtual queue in the memory for a consumable event. The virtual queue defines a current order of a plurality of a first class of agents for the consumable event. The queue manager is configured to summon one or more agents of the plurality of the first class of agents to the consumable event, and output an instruction to one or more agents of a plurality of a second class of agents configured to perform one or more actions related to the consumable event, wherein the queue manager is configured to communicate with a plurality of mobile devices, each mobile device of the plurality of mobile devices associated with an agent of the plurality of the first class of agents and to communicate with the plurality of the second class of agents.

Abstract: An image processing pipeline includes an image processing system having multiple neural networks arranged to receive multiple input images, with the images having identifiable objects and noise features. A first neural network provides image information to a second neural network that recurrently processes the image information to both improve output presentation of identifiable objects and reduce noise features. In some embodiments other local or remote neural networks can be arranged to modify at least one of an image capture setting, sensor processing, global post processing, local post processing, portfolio post processing, or provide latent vectors or neural embedding information.

Abstract: An image processing pipeline including a still or video camera includes an image processing system having a first neural network arranged to receive at least one input image from a video camera having noise features and feedback from a neural embedding. The neural network processes at least one input image and feedback from the neural embedding to provide a temporally consistent output image having reduced noise as compared to noise features in the at least one input image. In some embodiments a second neural network in the image processing system is arranged to modify at least one of an image capture setting, sensor processing, global post processing, local post processing, portfolio post processing, or provide latent vectors or neural embedding information.

Abstract: The present invention provides a system that comprises a memory and a queue manager that maintains a virtual queue in the memory for a consumable event, the virtual queue defining a current order of a plurality of agents, and summons one or more agents of the plurality of agents to the consumable event, wherein the queue manager is configured to communicate with a plurality of mobile devices, each mobile device of the plurality of mobile devices associated with an agent of the plurality of agents, wherein the queue manager communicates with each mobile device in order to monitor the associated agent, and wherein the queue manager is configured to dynamically determine when to summon one or more agents of the plurality of agents in the virtual queue to the consumable event based on the monitoring of the plurality of agents.

Abstract: This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

Abstract: A medical device system for tracking medical event times during patient treatment includes a medical device comprising a defibrillator/monitor and a mobile computing device including a communication interface configured to communicatively couple the mobile computing device to the medical device and receive patient data comprising medical information and time information comprising one or more medical events associated with the patient data, a display configured to provide a graphical user interface that provides the patient data and the time information, and one or more processors and associated memory, the one or more processors configured to control the graphical user interface to provide the patient data and the time information.

Abstract: This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

Abstract: Systems and methods to implement customer contact service with real-time agent assistance. A service of a computing resource service provider may establish a connection between an agent to obtain audio data of the agent and a customer, transcribe the audio data to generate at least a portion of a transcript, execute one or more natural language processing techniques to generate metadata associated with the transcript, determine, based at least in part on the metadata, whether one or more categories match the transcript, generate information by processing the transcript, the metadata, and the one or more categories, and provide, to the agent, a notification that encodes the information. Notifications may be provided in real-time, which may include suitable delay tolerances.

Abstract: Systems and methods to implement customer contact service with real-time supervisor assistance. A supervisor may oversee multiple agents in a customer contact service. A service of a computing resource service provider may monitor a plurality of audio connections at a service of a computing resource service provider, generate transcripts for the plurality of audio data, analyze the transcripts using a set of natural language processing (NLP) techniques to generate metadata, tag the transcripts with categories based at least in prat on the metadata, generate information for at least a portion of the plurality of connections based on the transcripts, metadata, and categories, and provide the information to a supervisor of the agents.

Abstract: Systems and methods which may be implemented in the context of a customer contact service. A service of a computing resource service provider may obtain, at a first service of a computing resource service provider, audio source data from a client of the computing resource service provider, generate an output from the audio data, wherein the output encodes: a transcript of the audio data generated by a second service, wherein the transcript is partitioned by speaker, metadata generated by a third service based at least in part on the transcript, and, one or more categories triggered by the transcript, wherein a fourth service is used to determine whether the one or more categories match the transcript, and providing the output to the client.

Abstract: Systems and methods to support searching and diagnostics capabilities in a customer contact service. Contacts data may be encoded as text (e.g., chat logs), audio (e.g., audio recordings), and various other modalities. A computing resource service provider may implement a service to receive, from a client, a request to perform a search with a specified set of parameters on a plurality of outputs associated with a plurality of contacts data, wherein the plurality of outputs are generated based at least in part by: transcripts generated based on audio data of the plurality of contacts data, metadata determined based the transcripts using one or more natural language processing (NLP) techniques, categories that are matched based at least in part on the transcripts, and search the plurality of outputs to obtain a search result determined based at least in part on the transcripts, metadata, and categories, and provide the search result to the client.

Abstract: This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

Abstract: A clinical data management system (1) has databases (20), processors in servers (2-4) which are programmed to process clinical data and communicate with user interfaces and external systems interfaces, and at least one database. The system imports source data from disparate clinical site sources into staging databases at refresh intervals, maintains data models, and maps data from the staging databases into the data models, and feeds data from the data models into data delivery databases. There is a uniform refresh frequency for the staging databases. The system output is regularly updated data for clinical site performance, quality and risk metrics to a clinical study team. The data mapper servers identify each of a plurality of source data stages, and transform data from each stage to one or more data models according to one or more mapsets, each mapset defining a transformation.

Abstract: A clinical data management system has databases, processors in servers which are programmed to process clinical data and communicate with user interfaces and external systems interfaces, and at least one database. The system imports source data from disparate clinical site sources into staging databases at refresh intervals, maintains data models, and maps data from the staging databases into the data models, and feeds data from the data models into data delivery databases. There is a uniform refresh frequency for the staging databases. The system output is regularly updated data for clinical site performance, quality and risk metrics to a clinical study team. The data mapper servers identify each of a plurality of source data stages, and transform data from each stage to one or more data models according to one or more mapsets, each mapset defining a transformation.

Abstract: The present invention provides a system that comprises a memory and a queue manager that maintains a virtual queue in the memory for a consumable event, the virtual queue defining a current order of a plurality of agents, and summons one or more agents of the plurality of agents to the consumable event, wherein the queue manager is configured to communicate with a plurality of mobile devices, each mobile device of the plurality of mobile devices associated with an agent of the plurality of agents, wherein the queue manager communicates with each mobile device in order to monitor the associated agent, and wherein the queue manager is configured to dynamically determine when to summon one or more agents of the plurality of agents in the virtual queue to the consumable event based on the monitoring of the plurality of agents.