Patents by Inventor Colin Thorpe

Colin Thorpe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for inducing bioorthogonal reactivity
    Patent number: 11485987
    Abstract: A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein the dihydrotetrazine 1 comprises a first R group and a second R group, wherein the first R group is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the second R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, and heteroatom-containing groups; wherein the method comprises (a) providing the dihydrotetrazine 1 in a reaction medium, and (b) adding an enzyme as a catalyst and an oxidant to the reaction medium, whereby the dihydrotetrazine 1 is converted to the tetrazine 2.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: November 1, 2022
    Assignee: University of Delaware
    Inventors: Joseph M. Fox, Colin Thorpe, Amanda M. Tallon, Yixin Xie, William Trout, Ashlyn S. Cantrel, Julia E. Rosenberger
  • Methods for inducing bioorthogonal reactivity
    Patent number: 10875840
    Abstract: A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,- or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: December 29, 2020
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Joseph Fox, Xinqiao Jia, Will Trout, Joel Rosenthal, Han Zhang, Yinzhi Fang, Colin Thorpe, Shuang Liu, Yixin Xie
  • Isolation of quiescin-sulfhydryl oxidase from milk
    Patent number: 7625733
    Abstract: Methods for isolating a highly purified QSOX enzyme from milk or whey are described. The enzyme may be used to generate intermolecular and intramolecular disulfide bridges and to facilitate oxidative protein folding.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: December 1, 2009
    Assignee: University of Delaware
    Inventors: Colin Thorpe, Jennifer Jaje
  • Isolation of quiescin-sulfhydryl oxidase from milk
    Publication number: 20090042269
    Abstract: Methods for isolating a highly purified QSOX enzyme from milk or whey are described. The enzyme may be used to generate intermolecular and intramolecular disulfide bridges and to facilitate oxidative protein folding.
    Type: Application
    Filed: July 24, 2008
    Publication date: February 12, 2009
    Inventors: Colin Thorpe, Jennifer Jaje
  • Acyl-CoA dehydrogenase allenic inhibitors
    Patent number: 7045547
    Abstract: Compounds of formula I wherein A is R3, OR3, SR3, and NR3R4; and R1, R2, R3 and R4 are as defined. The compounds of the invention are reversible inhibitors of acyl-CoA dehydrogenase, and are useful in treating disorders such as diabetes, heart diseases (including angina and congestive heart failure), and peripheral vascular disease in patients suffering from these diseases or conditions resulting thereof.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: May 16, 2006
    Assignee: University of Delaware
    Inventors: Colin Thorpe, Wenzhong Wang
  • Acyl-CoA dehydrogenase allenic inhibitors
    Publication number: 20040039032
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: August 20, 2002
    Publication date: February 26, 2004
    Inventors: Colin Thorpe, Wenzhong Wang