Patents by Inventor Colin Tuohey
Colin Tuohey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230313110Abstract: An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.Type: ApplicationFiled: June 7, 2023Publication date: October 5, 2023Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: RICHARD DAMREN, COLIN TUOHEY, RALPH STANKOWSKI
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Patent number: 11708555Abstract: An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.Type: GrantFiled: May 30, 2019Date of Patent: July 25, 2023Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard Damren, Colin Tuohey, Ralph Stankowski
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Publication number: 20220258166Abstract: The present invention relates to a bioprocess bag 118 comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port 142 and at least one outlet port 146. The bioprocess bag 118 also comprises a tube structure 400 comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure 400 comprising a reinforced portion 402 proximate the first opened-end.Type: ApplicationFiled: June 30, 2020Publication date: August 18, 2022Inventors: Colin TUOHEY, Ralph STANKOWSKI
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Publication number: 20220235304Abstract: A bioreactor vessel includes a bottom, a peripheral sidewall, the bottom and the peripheral sidewall defining an interior space for receiving a flexible bioprocessing bag, a recess in the bottom for receiving a base plate of the flexible bioprocessing bag, and a locking mechanism configured to retain the base plate in the recess.Type: ApplicationFiled: June 9, 2020Publication date: July 28, 2022Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: TIMOTHY BECKER, MANAS DASH, RALPH STANKOWSKI, COLIN TUOHEY, MICHELLE ANN PARZIALE, ELIZABETH STEGNER, ALEXANDER MARK KILAR, KANDAKUMAR MURUGESAN, PRASAD BAGIYANATHAN, SAIRAM CHERUNNI, NIKHIL VAGGA CHANDRAMOULI
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Publication number: 20220033755Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.Type: ApplicationFiled: September 7, 2021Publication date: February 3, 2022Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: COLIN TUOHEY, THOMAS ERDENBERGER, RICHARD DAMREN, MICHAEL FISHER, JOHN SWIBES
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Publication number: 20220023807Abstract: A sparger assembly (700) for a bioprocessing system includes a base plate (710) and at least one aeration manifold (712, 714) removably connected to tire base plate. Each aeration manifold includes at least one inlet for receiving a gas and a plurality of gas outlet openings for delivering tire gas to a fluid within the bioprocessing system. An impeller assembly (740) fora bioprocessing system includes a hub and at least one blade (742) operatively connected to the hub. The at least one blade includes a first portion connected to the hub and extending generally vertically, and a second portion extending at an upward angle from tire first portion.Type: ApplicationFiled: December 4, 2019Publication date: January 27, 2022Inventors: Richard Damren, Timothy Becker, Colin Tuohey, Ralph Stankowski, Sree Ramulu Bandaru, Saravanan Balakrishnan, Thomas Falkman, Pierre Le Greves, Tomas Dalmo, Nagaraj Rao, Mikael Petersson, Manas Dash
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Patent number: 11142737Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.Type: GrantFiled: February 22, 2012Date of Patent: October 12, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Colin Tuohey, Thomas Erdenberger, Richard Damren, Michael Fisher, John Swibes
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Patent number: 11130073Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: GrantFiled: January 27, 2020Date of Patent: September 28, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard Lee Damren, Colin Tuohey, Patrick Guertin, Parrish Galliher
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Publication number: 20210016287Abstract: The present invention involves a reinforced tubing structure that is particularly useful for reinforcing tubing that is present inside disposable bioreactor bags, including for example thermowell tubing.Type: ApplicationFiled: July 16, 2019Publication date: January 21, 2021Inventors: Colin TUOHEY, Ralph STANKOWSKI
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Publication number: 20200377841Abstract: An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.Type: ApplicationFiled: May 30, 2019Publication date: December 3, 2020Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: RICHARD DAMREN, COLIN TUOHEY, RALPH STANKOWSKI
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Publication number: 20200155962Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: ApplicationFiled: January 27, 2020Publication date: May 21, 2020Applicant: General Electric CompanyInventors: Richard Lee Damren, Colin Tuohey, Patrick Guertin, Parrish Galliher
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Patent number: 10576393Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: GrantFiled: December 18, 2015Date of Patent: March 3, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Richard Lee Damren, Colin Tuohey, Patrick Guertin, Parrish Galliher
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Publication number: 20180237736Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bio culture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant.Type: ApplicationFiled: April 17, 2018Publication date: August 23, 2018Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: COLIN TUOHEY, TED DELOGGIO, THOMAS ERDENBERGER, KENNETH P. CLAPP, RICHARD DAMREN, PARRISH M. GALLIHER, PATRICK GUERTIN, JIYOUNG LEE, MICHAEL FISHER
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Patent number: 9969965Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis.Type: GrantFiled: January 11, 2012Date of Patent: May 15, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin Tuohey, Ted Deloggio, Thomas Erdenberger, Kenneth P. Clapp, Richard Damren, Parrish M. Galliher, Patrick Guertin, Jiyoung Lee, Michael Fisher
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Patent number: 9719705Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, therebyType: GrantFiled: April 18, 2016Date of Patent: August 1, 2017Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Patric Fricking, Parrish Galliher, Geoffrey Hodge, Michael Fisher, Patrick Guertin, Richard Damren, Colin Tuohey, Thomas Erdenberger
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Publication number: 20170173493Abstract: Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.Type: ApplicationFiled: December 18, 2015Publication date: June 22, 2017Inventors: Richard Lee Damren, Colin Tuohey, Patrick GUERTIN, Parrish GALLIHER
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Publication number: 20160231036Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, therebyType: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Inventors: Patric FRICKING, Parrish GALLIHER, Geoffrey Hodge, Michael FISHER, Patrick GUERTIN, Richard DAMREN, Colin Tuohey, Thomas ERDENBERGER
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Publication number: 20130288346Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis.Type: ApplicationFiled: January 11, 2012Publication date: October 31, 2013Applicant: Xcellerex Inc.Inventors: Colin Tuohey, Ted Deloggio, Thomas Erdenberger, Kenneth P. Clapp, Richard Damren, Parrish M. Galliher, Patrick Guertin, Jiyoung Lee, Michael Fisher
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Publication number: 20120260671Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioretractor, forming a dry gas stream for entering or leaving the bioreactor.Type: ApplicationFiled: March 29, 2012Publication date: October 18, 2012Applicant: Xcellerex, Inc.Inventors: Richard L. DAMREN, Colin Tuohey, Thomas Erdenberger, Michael Fisher, Geoffrey L. Hodge, Patrick M. Guertin, Parrish M. Galliher
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Publication number: 20120238011Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.Type: ApplicationFiled: February 22, 2012Publication date: September 20, 2012Applicant: Xcellerex, Inc.Inventors: Colin Tuohey, Thomas Erdenberger, Richard Damren, Michael Fisher, John Swibes