Patents by Inventor Colin Wesley Ward

Colin Wesley Ward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure of the C-terminal region of the insulin receptor ?-chain and of the insulin-like growth factor receptor ?-chain
    Patent number: 8666718
    Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR ?-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: March 4, 2014
    Assignee: The Walter and Eliza Hall Institute of Medical Research
    Inventors: Michael Colin Lawrence, Brian John Smith, John Gerbrandt Tasman Menting, Colin Wesley Ward
  • Structure of the insulin receptor ectodomain
    Patent number: 8301398
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: October 30, 2012
    Assignee: Walter and Eliza Hall Institute of Medical Research
    Inventors: Thomas P. J. Garrett, Timothy Edward Adams, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN
    Publication number: 20120122771
    Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR ?-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
    Type: Application
    Filed: March 9, 2010
    Publication date: May 17, 2012
    Inventors: Michael Colin Lawrence, Brian John Smith, John Gerbrandt Tasman Menting, Colin Wesley Ward
  • Structure of the Insulin Receptor Ectodomain
    Publication number: 20100267927
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Application
    Filed: June 22, 2007
    Publication date: October 21, 2010
    Inventors: Thomas P.J. Garrett, Timothy Edward Admas, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • Truncated EGF Receptor
    Publication number: 20090117134
    Abstract: The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF1. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
    Type: Application
    Filed: October 20, 2008
    Publication date: May 7, 2009
    Applicants: Commonwealth Scientific and Industrial Research Organisation, Ludwig institute for Cancer Research
    Inventors: Colin Wesley WARD, Neil Moreton McKern, George Oscar Lovrecz, Robert Nicholas Jorissen, Thomas Peter John Garrett, Thomas Charles Elleman, Anthony Wilkes Burgess, Timothy Edward Adams, Teresa Anne Domagala, Edouard Nice
  • Truncated EGF receptor
    Patent number: 7449559
    Abstract: The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF1. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: November 11, 2008
    Assignees: Commonwealth Scientific and Industrial Research Organisation, Ludwig Insitutute for Cancer Research
    Inventors: Colin Wesley Ward, Neil Moreton McKern, George Oscar Lovrecz, Robert Nicholas Jorissen, Thomas Peter John Garrett, Thomas Charles Elleman, Antony Wilkes Burgess, Timothy Edward Adams, Teresa Anne Domagala, Edouard Collins Nice
  • Method of designing agonists and antagonists to IGF receptor
    Patent number: 7020563
    Abstract: Identification of the human insulin receptor binding site sequence of certain spatial molecular structures conforming to such binding site and of certain insulinomimetic sequences including the binding site sequence are disclosed.
    Type: Grant
    Filed: November 27, 1998
    Date of Patent: March 28, 2006
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: John David Bentley, Paul Alexander Tulloch, legal representative, Leah Jane Cosgrove, Maurice John Frenkel, Thomas Peter John Garrett, Lynne Jean Lawrence, Melzhen Lou, George Oscar Lovrecz, Colin Wesley Ward, Peter Archibald Tulloch, deceased
  • Truncated EGF receptor
    Patent number: 6946543
    Abstract: The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF-?. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: September 20, 2005
    Assignees: Commonwealth Scientific and Industrial Research Organisation, Ludwig Institute for Cancer Research
    Inventors: Colin Wesley Ward, Neil Morton McKern, George Oscar Lovrecz, Robert Nicholas Jorissen, Thomas Peter John Garrett, Thomas Charles Elleman, Antony Wilkes Burgess, Timothy Edward Adams, Teresa Anne Domagala, Edouard Nice
  • Methods of screening based on the egf receptor crystal structure
    Publication number: 20040248196
    Abstract: This invention relates to the structure of members of the epidermal growth factor (EGF) receptor family and to receptor/ligand interactions. In particular, it relates to the field of using the EGF receptor family structure to select and screen for compounds that inhibit the formation of active receptor dimers.
    Type: Application
    Filed: July 14, 2004
    Publication date: December 9, 2004
    Inventors: Timothy Edward Adams, Antony Wilks Burgess, Thomas Charles Elleman, Thomas Peter John Garrett, Robert Nicholas Jorissen, Meizhen Lou, George Oscar Lovrecz, Neil Moreton Mckern, Edouard Collins Nice, Colin Wesley Ward
  • Truncated egf receptor
    Publication number: 20030108953
    Abstract: The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TNFI. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
    Type: Application
    Filed: October 10, 2002
    Publication date: June 12, 2003
    Inventors: Colin Wesley Ward, Neil Moreton McKern, George Oscar Lovrecz, Robert Nicholas Jorissen, Thomas Peter John Garrett, Thomas Charles Elleman, Anthony Wilkes Burgess, Timothy Edward Adams, Teresa Anne Domagala, Edouard Nice