Abstract: This invention relates to berberine alkaloids, formulations thereof and their use for the prevention and/or treatment of infectious disease, especially disease caused by C. perfringens and Eimeria in animals. The invention also relates to improving the feed conversion ratio in a food producing animal by administering berberine compositions.

Abstract: Films including a water-soluble layer and a vapor-deposited organic coating are disclosed. The films can optionally further include a vapor-deposited inorganic layer. The films exhibit enhanced barrier properties.

Abstract: A method of removing tissue in a body lumen includes advancing a tissue-removing catheter over a guidewire in the body lumen to position a distal end of the catheter adjacent the tissue and a proximal end portion of the catheter outside of the body lumen. The catheter includes an elongate body, a tissue removing element mounted on a distal end portion of the elongate body, and an inner liner disposed within the elongate body. The inner liner defines a guidewire lumen in which the guidewire is disposed during the advancement of the catheter. The method further includes rotating the elongate body and tissue-removing element of the catheter to remove the tissue. Detecting wear of the inner liner caused by the elongate body contacting the inner liner during use.

Abstract: Techniques are described herein that are capable of registering a user device with a cloud-based management service using an intermediate cloud storage. For instance, the intermediate cloud storage may store an encrypted data blob including information that identifies the user device. The intermediate cloud storage or a registration system may decrypt the encrypted data blob so that the registration system may use the decrypted data blob to register the user device with the cloud-based management service. For instance, the registration system may retrieve the encrypted or decrypted data blob from the intermediate cloud storage by providing a requisite secret to the intermediate cloud storage. The requisite secret may be provided to the registration system by the user device (e.g., via a matrix barcode, such as a QR code).

Abstract: Methods for making films including a water-soluble polymeric material and a vapor-deposited inorganic coating are disclosed. The method comprises providing a layer of water-soluble polymeric material and vapor depositing an inorganic coating to at least one surface of the layer of water-soluble polymeric material, wherein the inorganic coating comprises a metal oxide. The method further comprises forming a plurality of microfractures extending along the surface of the inorganic coating.

Abstract: Non-viral nucleic acid delivery agents and methods for the delivery or transfer of nucleic acid molecules to target cells are disclosed. The agents comprise a complex of a nucleic acid cargo for delivery, one or more lipopeptide compound, and one or more polymeric charge-neutralising agent, and the complex is in the form of a particle with substantially neutral or negative surface charge. The agents and methods may be useful in a variety of applications such as therapies (including gene therapies and nucleic acid vaccinations) for diseases and medical disorders.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate body having an axis and proximal and distal end portions spaced apart from one another along the axis. A turbine is fixed to the elongate body and is disposed at an intermediate position between the proximal and distal end portions of the elongate body. A rotatable tissue-removing element is at the distal end portion of the elongate body and is operatively coupled to the turbine such that the turbine imparts rotation of the tissue-removing element. The tissue-removing element removes the tissue from the body lumen as the tissue-removing element is rotated by the turbine.

Abstract: Techniques are described herein that are capable of registering a user device with a cloud-based management service using an intermediate cloud storage. For instance, the intermediate cloud storage may store an encrypted data blob including information that identifies the user device. The intermediate cloud storage or a registration system may decrypt the encrypted data blob so that the registration system may use the decrypted data blob to register the user device with the cloud-based management service. For instance, the registration system may retrieve the encrypted or decrypted data blob from the intermediate cloud storage by providing a requisite secret to the intermediate cloud storage. The requisite secret may be provided to the registration system by the user device (e.g., via a matrix barcode, such as a QR code).

Abstract: A burner assembly for providing a flame and combustion gas to a plurality of inlets includes a burner frame having a channel formed therein. The channel extends parallel to a longitudinal plane defined by the plurality of inlets. A burner is mounted within the channel of the burner frame. The burner is arranged in fluid communication with the plurality of inlets. A burner bracket is used to mount the burner assembly within a burner box. The burner bracket defines a cavity within which the channel of the burner frame and the burner are positionable.

Abstract: Films including a water-soluble layer and a vapor-deposited organic coating are disclosed. The films can optionally further include a vapor-deposited inorganic layer. The films exhibit enhanced barrier properties.

Abstract: Films including a water-soluble polymeric material and a vapor-deposited inorganic coating are disclosed. The water-soluble polymeric material may comprise polyvinyl alcohol. The vapor-deposited inorganic coating may include a metal oxide. The vapor-deposited inorganic coating may include a plurality of microfractures. The films may form part of a package and/or a water-soluble unit dose article.

Abstract: Films including a water-soluble layer and a vapor-deposited organic coating are disclosed. The films can optionally further include a vapor-deposited inorganic layer. The films exhibit enhanced barrier properties.

Abstract: Techniques are described herein that are capable of registering a user device with a cloud-based management service using an intermediate cloud storage. For instance, the intermediate cloud storage may store an encrypted data blob including information that identifies the user device. The intermediate cloud storage or a registration system may decrypt the encrypted data blob so that the registration system may use the decrypted data blob to register the user device with the cloud-based management service. For instance, the registration system may retrieve the encrypted or decrypted data blob from the intermediate cloud storage by providing a requisite secret to the intermediate cloud storage. The requisite secret may be provided to the registration system by the user device (e.g., via a matrix barcode, such as a QR code).

Abstract: Methods for making films including a water-soluble polymeric material and a vapor-deposited inorganic coating are disclosed. The method comprises providing a layer of water-soluble polymeric material and vapor depositing an inorganic coating to at least one surface of the layer of water-soluble polymeric material, wherein the inorganic coating comprises a metal oxide. The method further comprises forming a plurality of microfractures extending along the surface of the inorganic coating.

Abstract: Generally described, one or more aspects of the present application correspond to a highly distributed replica of a volume stored in a networked elastic computing environment. First and second replicas of the volume can be synchronously replicated, and some implementations of the tertiary replica can be asynchronously replicated. The highly distributed nature of the tertiary replica supports parallel data transfer of the data of the volume, resulting in faster creation of backups and new copies of the volume.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate body and a tissue-removing element mounted on a distal end portion of the elongate body. The tissue-removing element is configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen. An inner liner is received within the elongate body. The inner liner defines a guidewire lumen. The inner liner isolates an interior of the guidewire lumen from the elongate body and tissue-removing element such that rotational forces are not transferred from the elongate body and tissue-removing element to the interior of the guidewire lumen when the elongate body and tissue-removing element are rotated during removal of tissue from the body lumen.

Abstract: This invention relates to berberine alkaloids, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals, particularly Lawsonia infection. In particular, the invention relates to berberine alkaloids, formulations thereof, and their application as antimicrobial agents in the prevention and/or treatment of infectious disease including bacterial, viral, parasitic or fungal infections, and for improving feed conversion ratio in food-producing animals. Also described is the use of berberine alkaloids as feed preservatives, added to feed compositions, and used in combination with further agents suitable for treating infectious disease.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate body and a tissue-removing element mounted on a distal end portion of the elongate body. The tissue-removing element is configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen. An inner liner is received within the elongate body. The inner liner defines a guidewire lumen. The inner liner isolates an interior of the guidewire lumen from the elongate body and tissue-removing element such that rotational forces are not transferred from the elongate body and tissue-removing element to the interior of the guidewire lumen when the elongate body and tissue-removing element are rotated during removal of tissue from the body lumen.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate body having an axis, and proximal and distal end portions spaced apart from one another along the axis. The elongate body is sized and shaped to be received in the body lumen. A tissue-removing element is mounted on the distal end portion of the elongate body. The tissue-removing element is configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen. An inner liner is received within the elongate body and defines a guidewire lumen. The inner liner is coupled to the tissue-removing element at a distal end portion of the inner liner. A coupling assembly is disposed in the tissue-removing element for coupling the inner liner to the tissue-removing element. The coupling assembly includes a bushing attached directly to the distal end portion of the inner liner.

Abstract: A method is described for revamping an ammonia production facility said ammonia production facility having a front end comprising one or more reformers fed with a hydrocarbon feedstock at a hydrocarbon feed stock feed rate and a high-temperature shift reactor fed with a reformed gas obtained from said one or more reformers and containing a fixed bed of iron-containing water-gas shift catalyst, said front end operating at a first steam-to-carbon ratio and a first pressure drop, said method comprising the steps of (i) replacing the iron-containing water-gas shift catalyst with a low-steam water-gas shift catalyst to form a modified front end, (ii) operating the modified front end at a second steam-to-carbon ratio and a second pressure drop, wherein the second steam-to-carbon ratio is at least 0.2 less than the first steam-to-carbon ratio and the second pressure drop is less than the first pressure drop, and (iii) increasing the hydrocarbon feed stock feed rate to said one or more reformers.