Abstract: A prosthetic hip joint implant comprises an acetabular liner having an acetabular liner inner surface and defining an acetabular recess, and a femoral component comprising a head having a head outer surface and defining a head recess, a shaft having a shaft proximal end and a shaft distal end disposed within the head recess, and a covering disposed on and fixedly secured to the head outer surface, the shaft distal end, head, and covering disposed within the acetabular liner recess such that the covering is in continuous contact with the acetabular liner inner surface. Polyaxial movement of the shaft distal end produces movement of the covering along the acetabular liner inner surface within the acetabular liner recess without producing relative movement between the covering and the head.

Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.

Abstract: Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.

Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.

Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.

Abstract: Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.

Abstract: One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.

Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.

Abstract: One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.