Patents by Inventor Colleen Alexander

Colleen Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for delivery of DNA-binding chemotherapy drugs using nanoparticles
    Patent number: 8632789
    Abstract: System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: January 21, 2014
    Assignee: Syracuse University
    Inventors: Mathew Maye, James Dabrowiak, Colleen Alexander
  • SYSTEM AND METHOD FOR DELIVERY OF DNA-BINDING CHEMOTHERAPY DRUGS USING NANOPARTICLES
    Publication number: 20120141550
    Abstract: System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.
    Type: Application
    Filed: November 1, 2011
    Publication date: June 7, 2012
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Mathew Maye, James Dabrowiak, Colleen Alexander