Patents by Inventor Colleen Brophy

Colleen Brophy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APPARATUS AND METHODS FOR MEASURING PERIPHERAL VENOUS PRESSURE AND APPLICATIONS OF SAME
    Publication number: 20140207062
    Abstract: In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only.
    Type: Application
    Filed: July 13, 2012
    Publication date: July 24, 2014
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Susan Eagle, Kevin Sexton, Colleen Brophy, Kyle Mitchell Hocking
  • Methods for promoting wound healing and/or reducing scar formation
    Patent number: 8765673
    Abstract: The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: July 1, 2014
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Catherine Parmiter, Elizabeth Furnish, Padmini Komalavilas
  • INTRAVENOUS ACCESS DEVICE HAVING INTEGRATED HEMODYNAMIC RESUSCITATION SYSTEM AND RELATED METHODS
    Publication number: 20140073973
    Abstract: One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 13, 2014
    Applicant: Vanderbilt University
    Inventors: Kevin Sexton, Susan Eagle, Kyle Hocking, Franz Baudenbacher, Colleen Brophy
  • Compositions and Methods for Treating Cutaneous Scarring
    Publication number: 20140072613
    Abstract: The described invention provides compositions, dressings and methods for treating a cutaneous scar in a subject. The compositions of the derived invention contains a pharmaceutical composition comprising a therapeutic amount of a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) inhibitor comprising an MK2 polypeptide inhibitor or a functional equivalent thereof, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 13, 2014
    Inventors: Cynthia Lander, Caryn Peterson, Colleen Brophy
  • METHODS FOR TREATING OR PREVENTING VASCULAR GRAFT FAILURE
    Publication number: 20130115256
    Abstract: The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition.
    Type: Application
    Filed: May 24, 2011
    Publication date: May 9, 2013
    Inventors: Cynthia Lander, Alyssa Panitch, Colleen Brophy, Brandon Seal
  • Compositions And Methods For Preventing Or Treating Diseases, Conditions, Or Processes Characterized By Aberrant Fibroblast Proliferation And Extracellular Matrix Deposition
    Publication number: 20120263680
    Abstract: The described invention provides compositions and methods for preventing or treating a disease, condition, or pathologic process characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject. The method includes administering a therapeutic amount of a pharmaceutical composition comprising a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 12, 2012
    Publication date: October 18, 2012
    Applicant: MOERAE MATRIX, INC.
    Inventors: Cynthia Lander, Colleen Brophy
  • Methods for Promoting Wound Healing and/or Reducing Scar Formation
    Publication number: 20120238508
    Abstract: The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
    Type: Application
    Filed: January 4, 2012
    Publication date: September 20, 2012
    Inventors: Colleen BROPHY, Alyssa Panitch, Catherine Parmiter, Elizabeth Furnish, Padmini Komalavilas
  • Reagents and methods for smooth muscle therapies
    Patent number: 8129332
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: March 6, 2012
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Padmini Komalavilas, Brandon Seal, Lokesh Joshi
  • Heat shock protein 20-related polypeptides and uses therefor
    Patent number: 8124579
    Abstract: The present invention provides novel HSP20-based polypeptides and pharmaceutical compositions thereof, and methods for using such polypeptides and pharmaceutical compositions for various therapeutic uses.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: February 28, 2012
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Elizabeth Furnish, Padmini Komalavilas, Catherin Dreiza, Alyssa Panitch
  • Methods for Treating or Preventing Vascular Graft Failure
    Publication number: 20110288036
    Abstract: The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition.
    Type: Application
    Filed: May 24, 2011
    Publication date: November 24, 2011
    Inventors: Cynthia Lander, Colleen Brophy, Brandon Seal
  • Reagents and methods for smooth muscle therapies
    Patent number: 8044018
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: October 25, 2011
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Padmini Komalavilas, Brandon Seal, Lokesh Joshi
  • Methods for Promoting Wound Healing and/or Reducing Scar Formation
    Publication number: 20100009903
    Abstract: The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
    Type: Application
    Filed: February 20, 2004
    Publication date: January 14, 2010
    Applicant: ARIZONA BOARD of REGENTS
    Inventors: Colleen Brophy, Alyssa Panitch, Catherine Parmiter, Elizabeth Furnish, Padmini Komalavilas
  • Novel Protein Transduction Domains and Uses Therefor
    Publication number: 20100004165
    Abstract: The present invention provides novel transduction domains, compositions comprising such transduction domains, and their use for in vivo molecular delivery.
    Type: Application
    Filed: October 30, 2006
    Publication date: January 7, 2010
    Applicant: The Arizona Board of Regents, a body corporate acting on behalf of Arizona State University
    Inventors: Colleen Brophy, Alyssa Panitch, Elizabeth Furnish, Brandon Seal
  • Reagents and Methods for Smooth Muscle Therapies
    Publication number: 20090258819
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Application
    Filed: April 11, 2008
    Publication date: October 15, 2009
    Inventors: Colleen Brophy, Padmini Komalavilas, Alyssa Panitch, Brandon Seal, Joshi Lokesh
  • Reagents and Methods for Smooth Muscle Therapies
    Publication number: 20090176695
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Application
    Filed: April 14, 2008
    Publication date: July 9, 2009
    Inventors: Colleen Brophy, Padmini Komalavilas, Alyssa Panitch, Brandon Seal, Joshi Lokesh
  • Reagents and Methods for Smooth Muscle Therapies
    Publication number: 20090176694
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Application
    Filed: April 11, 2008
    Publication date: July 9, 2009
    Inventors: Colleen Brophy, Padmini Komalavilas, Alyssa Panitch, Brandon Seal, Joshi Lokesh
  • Polypeptide inhibitors of HSP27 kinase and uses therefor
    Publication number: 20080293640
    Abstract: The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.
    Type: Application
    Filed: January 10, 2008
    Publication date: November 27, 2008
    Inventors: Colleen Brophy, Alyssa Panitch, Brandon Seal, Padmini Komalavilas, Luciana Lopes, Charles Robert Flynn
  • Novel Heat Shock Protein 20-Related Polypeptides and Uses Therefor
    Publication number: 20080132443
    Abstract: The present invention provides novel HSP20-based polypeptides and pharmaceutical compositions thereof, and methods for using such polypeptides and pharmaceutical compositions for various therapeutic uses.
    Type: Application
    Filed: October 15, 2004
    Publication date: June 5, 2008
    Applicant: Arizona Board of Regents
    Inventors: Colleen Brophy, Elizabeth Furnish, Padmini Komalavilas, Catherin Dreiza, Alyssa Panitch
  • Reagents and methods for smooth muscle therapies
    Patent number: 7381699
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20(HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 3, 2008
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Padmini Komalavilas, Alyssa Panitch, Brandon Seal, Lokesh Joshi
  • Reagents and methods for smooth muscle therapies
    Patent number: 7135453
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: November 14, 2006
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Padmini Komalavilas, Alyssa Panitch, Brandon Seal