Abstract: Medical devices useful in the delivery of chemotherapeutic agents, kits and methods are described. An example catheter comprises an elongate member having an elongate member proximal end, an elongate member distal end, and an elongate member main body extending between the elongate member proximal end and the elongate member distal end. The elongate member main body defines an elongate member circumferential wall, first, second, and third openings on the elongate member proximal end, a first heating lumen extending from the first opening toward the elongate member distal end, a second heating lumen extending from the second opening toward the elongate member distal end, and a treatment lumen extending from the third opening toward the elongate member distal end. The treatment lumen comprises a blind passage. The elongate member circumferential wall defines a plurality of passageways providing fluid communication between the treatment lumen and an environment external to the catheter.

Abstract: Methods of making medical devices are described. A method of making a medical device for delivering a bioactive includes preparing a suitable solution comprising the bioactive; placing a vessel containing the solution over a substrate comprising a biocompatible foam and defining open cells; initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate; and maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate. Medical devices made by the methods are also described.

Abstract: Various aspects of the present disclosure provide compositions, coatings and implantable devices including a drug and an excipient. In certain embodiments the excipient and the drug are present at a weight ratio of between 10 to 1 and 1 to 10 drug to excipient. In certain other embodiments, the excipient and the drug form particles in which the drug is encapsulated by the excipient. Other aspects of the disclosure provide methods of manufacturing and using such compositions, coatings and implantable devices.

Abstract: Various aspects of the present disclosure provide compositions, coatings and implantable devices including a drug and an excipient. In certain embodiments the excipient and the drug are present at a weight ratio of between 10 to 1 and 1 to 10 drug to excipient. In certain other embodiments, the excipient and the drug form particles in which the drug is encapsulated by the excipient. Other aspects of the disclosure provide methods of manufacturing and using such compositions, coatings and implantable devices.

Abstract: Medical devices for local bioactive delivery are described. A medical device includes a first biodegradable layer, a second biodegradable layer, and a bioactive disposed between the first and second biodegradable layers. The first and second biodegradable layers are positioned such that a surface of the first biodegradable layer faces a surface of the second biodegradable layer and such that a peripheral portion of one biodegradable layer is folded over a peripheral portion of the other biodegradable layer. Methods of making medical devices and methods of using medical devices are also described.

Abstract: Methods of making medical devices are described. A method of making a medical device for delivering a bioactive includes preparing a suitable solution comprising the bioactive; placing a vessel containing the solution over a substrate comprising a biocompatible foam and defining open cells; initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate; and maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate. Medical devices made by the methods are also described.

Abstract: Methods of making medical devices are described. A method of making a medical device for delivering a bioactive includes preparing a suitable solution comprising the bioactive; placing a vessel containing the solution over a substrate comprising a biocompatible foam and defining open cells; initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate; and maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate. Medical devices made by the methods are also described.

Abstract: Various aspects of the present disclosure provide compositions, coatings and implantable devices including a drug and an excipient. In certain embodiments the excipient and the drug are present at a weight ratio of between 10 to 1 and 1 to 10 drug to excipient. In certain other embodiments, the excipient and the drug form particles in which the drug is encapsulated by the excipient. Other aspects of the disclosure provide methods of manufacturing and using such compositions, coatings and implantable devices.

Abstract: Disclosed is a medical device constructed and arranged for contact with a flow of blood or other bodily fluid of a patient and including an attached binding agent or a roughened surface that binds to pathogenic cells targeted for elimination from the blood or other bodily fluid. Also disclosed are methods for making and using the device.

Abstract: Medical devices useful in the delivery of chemotherapeutic agents, kits and methods are described. An example catheter comprises an elongate member having an elongate member proximal end, an elongate member distal end, and an elongate member main body extending between the elongate member proximal end and the elongate member distal end. The elongate member main body defines an elongate member circumferential wall, first, second, and third openings on the elongate member proximal end, a first heating lumen extending from the first opening toward the elongate member distal end, a second heating lumen extending from the second opening toward the elongate member distal end, and a treatment lumen extending from the third opening toward the elongate member distal end. The treatment lumen comprises a blind passage. The elongate member circumferential wall defines a plurality of passageways providing fluid communication between the treatment lumen and an environment external to the catheter.

Abstract: Various aspects of the present disclosure provide compositions, coatings and implantable devices including a drug and an excipient. In certain embodiments the excipient and the drug are present at a weight ratio of between 10 to 1 and 1 to 10 drug to excipient. In certain other embodiments, the excipient and the drug form particles in which the drug is encapsulated by the excipient. Other aspects of the disclosure provide methods of manufacturing and using such compositions, coatings and implantable devices.

Abstract: Medical devices for local bioactive delivery are described. A medical device includes a first biodegradable layer, a second biodegradable layer, and a bioactive disposed between the first and second biodegradable layers. The first and second biodegradable layers are positioned such that a surface of the first biodegradable layer faces a surface of the second biodegradable layer and such that a peripheral portion of one biodegradable layer is folded over a peripheral portion of the other biodegradable layer. Methods of making medical devices and methods of using medical devices are also described.

Abstract: Medical devices for local bioactive delivery are described. A medical device has an elongate shaft extending between proximal and distal ends and a distal portion that defines a pigtail. A balloon is disposed on the elongate shaft proximal to the pigtail. The elongate shaft defines a first working lumen with a distal opening disposed between the balloon and the pigtail, and a second working lumen with a distal opening disposed distal to the first working lumen distal opening. Methods of using medical devices are also described.

Abstract: Methods of making medical devices are described. A method of making a medical device for delivering a bioactive includes preparing a suitable solution comprising the bioactive; placing a vessel containing the solution over a substrate comprising a biocompatible foam and defining open cells; initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate; and maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate. Medical devices made by the methods are also described.

Abstract: Various aspects of the present disclosure provide compositions, coatings and implantable devices including a drug and an excipient. In certain embodiments the excipient and the drug are present at a weight ratio of between 10 to 1 and 1 to 10 drug to excipient. In certain other embodiments, the excipient and the drug form particles in which the drug is encapsulated by the excipient. Other aspects of the disclosure provide methods of manufacturing and using such compositions, coatings and implantable devices.

Abstract: Described are embolization devices which carry M1 macrophage promoting agents and/or M2 macrophage inhibiting agents, as well as methods for their manufacture and use. An illustrative embolization device of the disclosure comprises an embolic body and one or more M1 macrophage promoting agents and/or M2 macrophage inhibiting agents carried by a surface of the embolic body. In certain embodiments the embolic body of the present disclosure comprises an embolic coil or an embolic bead.

Abstract: Disclosed is a medical device constructed and arranged for contact with a flow of blood or other bodily fluid of a patient and including an attached binding agent or a roughened surface that binds to pathogenic cells targeted for elimination from the blood or other bodily fluid. Also disclosed are methods for making and using the device.