Publication number: 20230048144
Abstract: The present disclosure provides, among other things, a single-dose vaccine composition that includes a chitosan adjuvant and HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82, where the single-dose vaccine composition provides enhanced or comparable HPV vaccine response in comparison to a similar multiple-dose vaccine formulated without such chitosan adjuvant.
Type:
Application
Filed:
August 4, 2022
Publication date:
February 16, 2023
Applicant:
Merck Sharp & Dohme LLC
Inventors:
Andrew Bett, Colleen M. Barr, John P. Bilello, Pedro J. Cejas, Amy S. Espeseth, Tong-Ming Fu, Erica L. Strable, Sara Zimmermann