Patents by Inventor Collin E. Thomas

Collin E. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic and epigenetic manipulation of ABC transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors
    Publication number: 20020173031
    Abstract: The present invention relates to methods for modulating the resistance of cells to foreign compounds, i.e. drugs, antibiotics, etc by altering the ATP gradient across biological membranes. The altering of the ATP gradient across biological membranes is achieved through the manipulation of ecto-phosphatase activity and ABC transporter molecule activity which may be useful to confer herbicide resistance to plants, confer antibiotic resistance to bacteria, confer drug resistance to yeast cells, or to reduce resistance in cells to facilitate chemotherapeutic treatments, and to reduce resistance in bacteria and yeast. The present invention is also directed to the methods for identifying ecto-phosphatase inhibitors and uses thereof.
    Type: Application
    Filed: January 14, 2002
    Publication date: November 21, 2002
    Applicant: The University of Texas System
    Inventors: Collin E. Thomas, J. Brian Windsor, Stan J. Roux, Alan M. Lloyd, Laurence Hurley
  • Genetic and epigenetic manipulation of ABC transporters and ectophosphatases for the conference of hormone and herbicide resistance
    Patent number: 6448472
    Abstract: The present invention relates to methods for modulating the resistance of cells to foreign compounds, i.e. drugs, antibiotics, etc by altering the ATP gradient across biological membranes. The altering of the ATP gradient across biological membranes is achieved through the manipulation of ecto-phosphatase activity and ABC transporter molecule activity which may be useful to confer herbicide resistance to plants, confer antibiotic resistance to bacteria, confer drug resistance to yeast cells, or to reduce resistance in cells to facilitate chemotherapeutic treatments, and to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease.
    Type: Grant
    Filed: February 5, 1999
    Date of Patent: September 10, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Collin E. Thomas, J. Brian Windsor, Stan J. Roux, Alan M. Lloyd