Patents by Inventor Collin J. Weber

Collin J. Weber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9901548
    Abstract: This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments, the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: February 27, 2018
    Assignee: EMORY UNIVERSITY
    Inventors: Collin J. Weber, Susan A. Safley, Kereen S. Gordon, Nicholas E. Simpson
  • Publication number: 20150174273
    Abstract: It has been discovered that human parathyroid tumor cells express high densities of folate receptors which could provide a target that may be used for localization. In certain embodiments, the disclosure relates to methods of detecting and imaging parathyroid tumors or canccrous cells in tissues using a folatc conjugate to enhance imaging techniques such as magnetic resonance imaging, positron emission tomography, computed tomography (CT), and single-photon emission computed tomography (SPECT). An image of radioactivities or nuclear magnetic resonance frequencies as a function of location for parcels (voxels), may be constructed and plotted. The image shows the tissues in which the tracer has become concentrated.
    Type: Application
    Filed: July 24, 2013
    Publication date: June 25, 2015
    Applicant: EMORY UNIVERSITY
    Inventor: Collin J. Weber
  • Publication number: 20140105974
    Abstract: This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.
    Type: Application
    Filed: March 14, 2012
    Publication date: April 17, 2014
    Applicant: EMORY UNIVERSITY
    Inventors: Collin J. Weber, Susan A. Safley, Kereen S. Gordon, Nicholas E. Simpson
  • Patent number: 7041634
    Abstract: This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: May 9, 2006
    Assignees: Emory University, Bristol Myers-Squibb Company
    Inventors: Collin J. Weber, Mary K. Hagler, Peter S. Linsley, Judith A. Kapp, Susan A. Safley
  • Publication number: 20040047890
    Abstract: This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4.
    Type: Application
    Filed: March 27, 1998
    Publication date: March 11, 2004
    Inventors: COLLIN J. WEBER, MARY K. HAGLER, PETER S. LINSLEY, JUDITH A. KAPP, SUSAN A. SAFLEY
  • Patent number: 5795570
    Abstract: A core material such as animal tissue or cells is contained within a semipermeable vessel which may be a microcapsule, hollow fiber or plastic membrane having a semipermeable wall by a method that prevents the core material from incorporation into the wall of the vessel. This is accomplished by suspending the core material in a solution of polysaccharide gum such as an alkali metal alginate in an amount between about 0.2% and about 0.5%, removing and washing the core material to remove all but a thin layer of polysaccharide gum, and gelling the polysaccharide gum with multivalent cations or other means to form a pretreated core material.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: August 18, 1998
    Assignee: Emory University
    Inventors: Collin J. Weber, Jennifer Ayres-Price
  • Patent number: 5227298
    Abstract: The subject invention provides a method of encapsulating viable tissue or cells within a double walled bead, the double-walled bean produced as a result of the method, as well as a method of pretreating the tissue or cells with an immunosuppressant such as UV-B irradiation prior to their encapsulation.
    Type: Grant
    Filed: August 17, 1990
    Date of Patent: July 13, 1993
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Collin J. Weber, Janet E. Norton, Keith Reemtsma