Abstract: A medication delivery and adherence system, comprises a housing configured to mechanically connect to a portable computing and communication device, a controller disposed within the housing and communicatively connected to the portable computing and communication device, at least one removable sleeve disposed within the housing, the at least one sleeve configured to hold at least one dose of a medication, and at least one electromechanical actuator electrically connected to the controller, the electromechanical actuator configured to dispense the at least one dose of medication from the at least one sleeve. A method of verifying patient adherence to a treatment regimen is also described.