Patents by Inventor Colm O'Murchu

Colm O'Murchu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of a racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivative
    Patent number: 6262295
    Abstract: A process for the preparation of a racemic or optically active compound of the formula where the group R1 is an unsubstituted or a halogen substituted C1-4-alkyl, a C1-4-alkoxy, an aryl, an arylalkyl, an aryloxy, or arylalkylloxy.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: July 17, 2001
    Assignee: Lonza A.G.
    Inventors: Christine Bernegger, Eva Maria Urban, Olwen Mary Birch, Kurt Burgdorf, Frank Brux, Kay-Sara Etter, Pierre Bossard, Walter Brieden, Laurent Duc, John Gordon, Colm O'Murchu, Yves Guggisberg
  • Process for the preparation of an enantiomer of a (1R, 4S) or (1S, 4R)-1-amino-4-(hydroxymethyl)-2-cyclopentene derivative
    Patent number: 6252112
    Abstract: A novel process for the preparation of (1S, 4R)- or (1R, 4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2 -cyclopentene-1-methanol of the formula is described.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: June 26, 2001
    Assignee: Lonza A.G.,
    Inventors: Christine Bernegger, Eva Maria Urban, Olwen Mary Birch, Kurt Burgdorf, Frank Brux, Kay-Sara Etter, Pierre Bossard, Walter Brieden, Laurent Duc, John Gordon, Colm O'Murchu, Yves Guggisberg
  • Process for the preparation of (1S,4R)- or (1R,4S)- 4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol
    Patent number: 6156893
    Abstract: A novel process for the preparation of (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclo-pentene-1-methanol of the formulae ##STR1## is described. This entails in the first stage (.+-.)-2-aza-bicyclo[2.2.1]hept-5-en-3-one of the formula ##STR2## being acylated to give a (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one derivative of the general formula ##STR3## in which R.sup.1 denotes C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, aryl or aryloxy, the latter being reduced in the second stage to give a cyclopentene derivative of the general formula ##STR4## in which R.sup.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: December 5, 2000
    Assignee: Lonza A.G.
    Inventors: Christine Bernegger, Eva Maria Urban, Olwen Mary Birch, Kurt Burgdorf, Frank Brux, Kay-Sara Etter, Pierre Bossard, Walter Brieden, Laurent Duc, John Gordon, Colm O'Murchu, Yves Guggisberg
  • Enantiomer compositions of (1R,4S)-1-butyrylamino-4-(hydroxymethyl)-2-cyclopentene
    Patent number: 6137007
    Abstract: A novel process for the preparation of (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol of the formulae ##STR1## is described. This entails in the first stage (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one of the formula ##STR2## being acylated to give a (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one derivative of the general formula ##STR3## in which R.sup.1 denotes C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, aryl or aryloxy, the latter being reduced in the second stage to give a cyclopentene derivative of the general formula ##STR4## in which R.sup.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: October 24, 2000
    Assignee: Lonza AG
    Inventors: Christine Bernegger, Eva Maria Urban, Olwen Mary Birch, Knut Burgdorf, Frank Brux, Kay-Sara Etter, Pierre Bossard, Walter Brieden, Laurent Duc, John Gordon, Colm O'Murchu, Yves Guggisberg
  • Process for the production of malonic acid anhydride
    Patent number: 5210222
    Abstract: A process, which is harmless with respect to safety, for the production of malonic acid anhydride. For this purpose, diketene is ozonized in the presence of a suitable carbonyl compound. Malonic acid anhydride is a highly reactive intermediate product for the synthesis of numerous active ingredients for, e.g., pharmaceutical agents, pesticides or dyes.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: May 11, 1993
    Assignee: Lonza Ltd.
    Inventor: Colm O'Murchu
  • Process for the preparation of 2-substituted 5-nitroso-4,6-diaminopyrimidines
    Patent number: 4831139
    Abstract: Process for the preparation of 2-substituted 5-nitroso-4,6-diaminopyrimidines. Malonic dinitrile and amidine are nitrosated in the presence of a nitrite salt, to form the corresponding amidine salt of isonitrosomalononitrile. The latter is converted to the end product in the presence of an aprotic polar solvent by heat treatment in a basic medium.
    Type: Grant
    Filed: September 13, 1988
    Date of Patent: May 16, 1989
    Assignee: Lonza Ltd.
    Inventor: Colm O'Murchu
  • Process for the production of indole
    Patent number: 3984434
    Abstract: This process involves the production of indole by catalytic dehydrocyclization. The process includes reacting, without the addition of free oxygen and/or a gas containing free oxygen, reacting o-ethylaniline and/or o-aminostyrene with steam in the presence of a particular catalyst. The catalyst contains at least one alkali compound and/or at least one alkaline earth compound and/or at least one compound containing iron, cobalt, chromium, vanadium, titanium, zinc, copper and/or zirconium.
    Type: Grant
    Filed: September 12, 1974
    Date of Patent: October 5, 1976
    Assignee: Lonza Ltd.
    Inventor: Colm O'Murchu