Patents by Inventor Conary Meyer

Conary Meyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Versatile, high-yield protein production ex vivo
    Patent number: 11453902
    Abstract: A cell lysate or cell-free protein synthesis system comprising recombinant translational proteins and uses thereof are provided.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: September 27, 2022
    Assignee: The Regents of the University of California
    Inventors: Cheemeng Tan, Luis Eduardo Contreras Llano, Conary Meyer, Fernando Villarreal
  • VERSATILE, HIGH-YIELD PROTEIN PRODUCTION EX VIVO
    Publication number: 20200407765
    Abstract: A cell lysate or cell-free protein synthesis system comprising recombinant translational proteins and uses thereof are provided.
    Type: Application
    Filed: June 29, 2020
    Publication date: December 31, 2020
    Inventors: Cheemeng TAN, Luis Eduardo Contreras LLANO, Conary MEYER, Fernando VILLARREAL
  • Engineered exosomes for the delivery of bioactive cargo using transmembrane VSV-G
    Patent number: 10758486
    Abstract: Vesicular stomatitis virus glycoprotein (VSVG) can both load protein cargo onto exosomes and increase their delivery ability via a pseudotyping mechanism. By fusing a set of fluorescent and luminescent reporters with VSVG, we show the successful targeting and incorporation of VSVG fusions into exosomes by gene transfection and fluorescence tracking. VSVG pseudotyping of exosomes does not affect the size or distributions of the exosomes, and both the full-length VSVG and the VSVG without the ectodomain integrate into the exosomal membrane, suggesting that the ectodomain is not required for protein loading. Finally, exosomes pseudotyped with full-length VSVG are internalized by multiple-recipient cell types to a greater degree compared to exosomes loaded with VSVG without the ectodomain, confirming a role of the ectodomain in cell tropism.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: September 1, 2020
    Assignee: Santa Clara University
    Inventors: Biao Lu, Conary Meyer, Joseph Losacco, Zachary Stickney
  • Engineered exosomes for the delivery of bioactive cargo using transmembrane tetraspanins
    Patent number: 10617768
    Abstract: Engineered exosomes for the delivery of bioactive cargo are provided. The exosomes incorporate a tetraspanin transmembrane anchoring scaffold onto the membrane of the exosome. The tetraspanin transmembrane anchoring scaffold has a C-terminal attachment site in the inner-vesicle space of the exosome, a N-terminal attachment site in the inner-vesicle space or the outer-vesicle space, and/or a loop attachment site in the outer-vesicle space. Peptides can be attached to the different attachments sites in any form or combination. Tetrapanins naturally anchor on the exosome membrane, are biocompatible, and allow for robust loading and delivery of bioactive cargos in mammalian system.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 14, 2020
    Assignee: Santa Clara University
    Inventors: Biao Lu, Conary Meyer, Joseph Losacco, Zachary Stickney
  • Engineered Exosomes for the Delivery of Bioactive Cargo Using Transmembrane VSV-G
    Publication number: 20190015333
    Abstract: Vesicular stomatitis virus glycoprotein (VSVG) can both load protein cargo onto exosomes and increase their delivery ability via a pseudotyping mechanism. By fusing a set of fluorescent and luminescent reporters with VSVG, we show the successful targeting and incorporation of VSVG fusions into exosomes by gene transfection and fluorescence tracking. VSVG pseudotyping of exosomes does not affect the size or distributions of the exosomes, and both the full-length VSVG and the VSVG without the ectodomain integrate into the exosomal membrane, suggesting that the ectodomain is not required for protein loading. Finally, exosomes pseudotyped with full-length VSVG are internalized by multiple-recipient cell types to a greater degree compared to exosomes loaded with VSVG without the ectodomain, confirming a role of the ectodomain in cell tropism.
    Type: Application
    Filed: July 12, 2018
    Publication date: January 17, 2019
    Inventors: Biao Lu, Conary Meyer, Joseph Losacco, Zachary Stickney
  • Engineered Exosomes for the Delivery of Bioactive Cargo Using Transmembrane Tetraspanins
    Publication number: 20180015182
    Abstract: Engineered exosomes for the delivery of bioactive cargo are provided. The exosomes incorporate a tetraspanin transmembrane anchoring scaffold onto the membrane of the exosome. The tetraspanin transmembrane anchoring scaffold has a C-terminal attachment site in the inner-vesicle space of the exosome, a N-terminal attachment site in the inner-vesicle space or the outer-vesicle space, and/or a loop attachment site in the outer-vesicle space. Peptides can be attached to the different attachments sites in any form or combination. Tetrapanins naturally anchor on the exosome membrane, are biocompatible, and allow for robust loading and delivery of bioactive cargos in mammalian system.
    Type: Application
    Filed: July 12, 2017
    Publication date: January 18, 2018
    Inventors: Biao Lu, Conary Meyer, Joseph Losacco, Zachary Stickney