Patents by Inventor Conceicao Minetti

Conceicao Minetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified immunogenic pneumolysin compositions as vaccines
    Publication number: 20050070695
    Abstract: This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also provides a method for generating novel pneumolysin variants with these desired characteristic properties. The invention also provides immunogenic compositions useful as pharmaceutical compositions including vaccines in which non-toxic, modified pneumolysin is used to stimulate protective immunity against Streptococcus pneumoniae. The vaccines may be compositions in which the modified pneumolysin is conjugated to bacterial polysaccharides or may be carried on an attenuated viral vector.
    Type: Application
    Filed: February 23, 2004
    Publication date: March 31, 2005
    Inventors: Conceicao Minetti, Francis Michon, Jeffrey Pullen, Mary Polvino-Bodnar, Shu-Mei Liang, Joseph Tai
  • Modified immunogenic pneumolysin compositions as vaccines
    Patent number: 6764686
    Abstract: This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also provides a method for generating novel pneumolysin variants with these desired characteristic properties. The invention also provides immunogenic compositions useful as pharmaceutical compositions including vaccines in which non-toxic, modified pneumolysin is used to stimulate protective immunity against Streptococcus pneumoniae. The vaccines may be compositions in which the modified pneumolysin is conjugated to bacterial polysaccharides or may be carried on an attenuated viral vector.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: July 20, 2004
    Assignee: Baxter International Inc.
    Inventors: Conceicao Minetti, Francis Michon, Jeffrey K. Pullen, Mary Ellen Polvino-Bodnar, Shu-Mei Liang, Joseph Y. Tai
  • MODIFIED IMMUNOGENIC PNEUMOLYSIN COMPOSITIONS AS VACCINES
    Publication number: 20010014332
    Abstract: This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also provides a method for generating novel pneumolysin variants with these desired characteristic properties. The invention also provides immunogenic compositions useful as pharmaceutical compositions including vaccines in which non-toxic, modified pneumolysin is used to stimulate protective immunity against Streptococcus pneumoniae. The vaccines may be compositions in which the modified pneumolysin is conjugated to bacterial polysaccharides or may be carried on an attenuated viral vector.
    Type: Application
    Filed: July 21, 1998
    Publication date: August 16, 2001
    Applicant: NORTH AMERICAN VACCINE, INC.
    Inventors: CONCEICAO MINETTI, FRANCIS MICHON, JEFFREY K. PULLEN, MARYELLEN POLVINO-BODNAR, SHU-MEI LIANG, JOSEPH Y. TAI