Abstract: Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. The coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. The coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: The Ejaculation Cap is a containment chamber and receptacle for semen from the penis resulting from sexual activity. The device is tubular with a closed end and an open end with the body of the device to covering the length of the penis. The closed end can be flat, circular, or gusseted. The material used can be of some soft, flushable, disposable or lubricated tissue or washable fabric. The construction can be seamed or seamless and made to fit different sized penises. The purpose of the device is to enhance cleanliness, but construction and/or materials can include features that also enhance pleasure.

Abstract: A dispenser apparatus and a dispenser system for dispensing a liquid from a bottle having a neck portion consisting of a housing formed with a flow conduit therethrough in fluid communication with the liquid within the bottle, the flow conduit having an inlet conduit, an outlet conduit and a substantially cylindrical cavity positioned between the inlet conduit and the outlet conduit, a flow wheel positioned in the cavity, the flow wheel having a central axis and a plurality of blade elements extending outwardly relative to the central axis, a flow sensor positioned adjacent to the flow wheel and the cavity for detecting movement of the plurality of blade elements of flow wheel, an electromagnetic valve positioned proximate to the outlet conduit, the electromagnetic valve having an actuation unit outside of the outlet conduit, a valve member inside the outlet conduit, and a spring member biased against the valve member within the outlet conduit, the valve member rotatable between a closed position and an open

Abstract: A dispenser apparatus and a dispenser system for dispensing a liquid from a bottle having a neck portion consisting of a housing formed with a flow conduit therethrough in fluid communication with the liquid within the bottle, the flow conduit having an inlet conduit, an outlet conduit and a substantially cylindrical cavity positioned between the inlet conduit and the outlet conduit, a flow wheel positioned in the cavity, the flow wheel having a central axis and a plurality of blade elements extending outwardly relative to the central axis, a flow sensor positioned adjacent to the flow wheel and the cavity for detecting movement of the plurality of blade elements of flow wheel, an electromagnetic valve positioned proximate to the outlet conduit, the electromagnetic valve having an actuation unit outside of the outlet conduit, a valve member inside the outlet conduit, and a spring member biased against the valve member within the outlet conduit, the valve member rotatable between a closed position and an open