Patents by Inventor Cong-Qiu Chu

Cong-Qiu Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamer-RNAi therapeutic compositions
    Patent number: 9926565
    Abstract: A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of ROR?2 is described herein. Pharmaceutical compositions comprising the recombinant nucleic acid, particularly topical compositions are also described. Methods of treating inflammatory disease using the pharmaceutical composition are also described.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: March 27, 2018
    Inventor: Cong-Qiu Chu
  • METHODS FOR REPAIRING CARTILAGE DAMAGE
    Publication number: 20170197011
    Abstract: A method for repairing cartilage damage comprising (a) creating a microfracture or performing other bone marrow stimulation techniques on a patient inflicted with cartilage damage; and (b) administering a composition to the microfracture, wherein the composition comprises an agent capable of regenerating organized hyaline cartilage.
    Type: Application
    Filed: June 5, 2015
    Publication date: July 13, 2017
    Inventors: Cong-Qiu CHU, Yong ZHU, Shili WU, Jun BAO
  • Aptamer-RNAi therapeutic compositions
    Patent number: 9683239
    Abstract: A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of ROR?2 is described herein. Pharmaceutical compositions comprising the recombinant nucleic acid, particularly topical compositions are also described. Methods of treating inflammatory disease using the pharmaceutical composition are also described.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: June 20, 2017
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventor: Cong-Qiu Chu
  • APTAMER-RNAi THERAPEUTIC COMPOSITIONS
    Publication number: 20160083731
    Abstract: A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of ROR?2 is described herein. Pharmaceutical compositions comprising the recombinant nucleic acid, particularly topical compositions are also described. Methods of treating inflammatory disease using the pharmaceutical composition are also described.
    Type: Application
    Filed: September 22, 2015
    Publication date: March 24, 2016
    Inventor: Cong-Qiu Chu
  • COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR REPAIRING CARTILAGE DAMAGE
    Publication number: 20140289882
    Abstract: The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
    Type: Application
    Filed: July 19, 2012
    Publication date: September 25, 2014
    Applicants: OREGON HEALTH AND SCIENCE UNIVERSITY, VIVOSCRIPT, INC.
    Inventors: Yong Zhu, Shili Wu, Jun Bao, Cong-Qiu Chu