Patents by Inventor Congcong HE

Congcong HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS TO IMPROVE IPSC-EC FUNCTION
    Publication number: 20240010992
    Abstract: Provided herein are compositions and methods to promote longevity of induced pluripotent stem cell (iPSC)-derived endothelial cells (ECs) via autophagy. In particular, provided herein are AMP-activated protein kinase (AMPK) activators, such as ginsenosides (e.g., Rg2), and use thereof to increase longevity of iPSC-ECs by stimulating mTOR-independent ULK1-mediated autophagy.
    Type: Application
    Filed: July 11, 2023
    Publication date: January 11, 2024
    Inventors: Katherine E. Hekman, Jason A. Wertheim, Congcong He
  • Autophagy inducers for treatment of CNS conditions
    Patent number: 11241436
    Abstract: The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: February 8, 2022
    Assignees: Northwestern University, The United States of Americans represented by the Secretary, Department of Health and Human Services, University of Kansas
    Inventors: Congcong He, Sui Huang, Chen Wang, Altea Rocchi, Juan Jose Marugan, Marc Ferrer, Samarjit Patnaik, Yuchi Chen, Kevin Frankowski, Frank J. Schoenen
  • METHOD AND APPARATUS FOR CLIPPING NEURAL NETWORKS AND PERFORMING CONVOLUTION
    Publication number: 20210279586
    Abstract: Methods and apparatuses of clipping a neural network and calculating a convolution of a neural network are provided. A method of clipping a neural network includes selecting a kernel slice of an input channel of a convolution layer in the neural network based on a convolution parameter of the convolution layer, determining a kernel slice similar to the selected kernel slice, determining a substitute slice for the selected kernel slice, based on the similar kernel slice, and clipping the selected kernel slice and replacing the clipped kernel slice by the substitute slice. The convolution parameter may include a number of input channels of the convolution layer, a number of output channels, and a width and a height of a filter of a convolution kernel of the convolution layer.
    Type: Application
    Filed: March 3, 2021
    Publication date: September 9, 2021
    Applicant: Samsung Electronics Co., Ltd.
    Inventors: CongCong HE, Jian ZHAO, Min YANG, Peng LEI
  • AUTOPHAGY INDUCERS FOR TREATMENT OF CNS CONDITIONS
    Publication number: 20200009146
    Abstract: The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.
    Type: Application
    Filed: January 25, 2018
    Publication date: January 9, 2020
    Applicants: Northwestern University, The United States of America, as Represented by the Secretary, Department of Health & Human Services, University of Kansas
    Inventors: Congcong HE, Sui HUANG, Chen WANG, Altea ROCCHI, Juan Jose MARUGAN, Marc FERRER, Samarjit PATNAIK, Yuchi CHEN, Kevin FRANKOWSKI, Frank J. SCHOENEN