Patents by Inventor Congcong ZHANG
Congcong ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959238Abstract: A system for a sandy soil landfill solid waste polluted river channel, includes a ground water interception and diversion system and a river channel ecological remediation system. The ground water interception and diversion system includes a water intake well arranged upstream of ground water in a landfill area, a buffer pool communicated with the water intake well, and a wastewater treatment system communicated with the buffer pool. The water intake well, the buffer pool, and the wastewater treatment system are communicated through a wastewater pipe. An electric wastewater valve and a variable frequency water pump are arranged on the wastewater pipe in sequence. The river channel ecological remediation system includes an impermeable layer arranged at a bottom of a river channel and ecological bank protections arranged on both sides of a river channel slope.Type: GrantFiled: November 24, 2023Date of Patent: April 16, 2024Assignee: Nanjing Institute of Environmental Sciences, MEEInventors: Houhu Zhang, Xiaofei Yan, Jinglong Liu, Lichen Liang, Congcong Sun, Xiang Chen, Cheng Zhang
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Patent number: 11952401Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.Type: GrantFiled: July 14, 2021Date of Patent: April 9, 2024Assignee: Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural SciencesInventors: Haixue Zheng, Fan Yang, Zixiang Zhu, Xiangle Zhang, Weijun Cao, Congcong Wang, Kangli Li, Huisheng Liu, Hong Tian, Keshan Zhang, Xiangtao Liu
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Publication number: 20240092899Abstract: Provided is a bispecific antibody, comprising a first antigen-binding moiety and a second antigen-binding moiety, wherein a paired domain of the first antigen-binding moiety comprises an amino acid sequence of engineered HLA-I ?3 and an amino acid sequence of engineered ?2M. Also provided are an expression method for the bispecific antibody, a polynucleotide encoding the bispecific antibody, a vector and host cell containing the polynucleotide, a pharmaceutical composition containing the bispecific antibody, a fusion protein, and a conjugate.Type: ApplicationFiled: January 27, 2022Publication date: March 21, 2024Inventors: Liangliang WANG, Zhengping ZHANG, Congcong SUN, Rongjuan ZHAO, Yimeng LI
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Publication number: 20230335989Abstract: A mesoscale data-based automatic wind turbine layout method and device. The method comprises: initially screening an input wind field region on the basis of input mesoscale wind map data by means of a wind speed limit value to obtain a first wind field region; re-screening the first wind field region on the basis of input terrain data by means of a slope limit value to obtain a second wind field region; and determining, by means of tabu search in which a target wind turbine count and the second wind field region are used as inputs, a wind turbine layout that optimizes an objective function, wherein the objective function is the sum of the annual energy production for wind turbine locations.Type: ApplicationFiled: June 26, 2023Publication date: October 19, 2023Inventors: Chuikuan ZENG, Congcong ZHANG, Xiaolong XU
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Publication number: 20210128615Abstract: The present invention pertains to methods and compounds useful in a therapy involving the administration of immune cells to a patient. The method of the invention involves the modification of cells of the immune system with agonists or antagonists of immune regulators such as Interleukin-10 (IL-10) or IL-6, in order to enhance and improve the immunological potential of the immune cells for therapy. Cells modified according to the method of the invention can be administered to a patient to support a treatment of proliferative diseases such as cancer or autoimmune disorders.Type: ApplicationFiled: October 18, 2018Publication date: May 6, 2021Inventors: Winfried Wels, Anja Waldmann, Congcong Zhang, Manuel Kaulich
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Publication number: 20200403179Abstract: An organic light-emitting diode (OLED) display panel and an OLED display device are provided. The OLED display panel, by providing an auxiliary water-oxygen barrier layer between the light-emitting functional layer and the substrate, water-oxygen can be isolated by the auxiliary water-oxygen barrier layer even through the gap between the second flexible layer and the second flexible layer and the second barrier layer, thus preventing erosion of the light-emitting functional layer and improving the water-oxygen isolation capacity of the OLED display panels. The technical problem that current active-matrix organic light-emitting diode (AMOLED) display panels, having a poor ability to isolate water-oxygen, is solved.Type: ApplicationFiled: September 23, 2019Publication date: December 24, 2020Inventors: Kai HU, Cuiyu HAO, Boyu SU, Li HE, Congcong ZHANG
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Publication number: 20200311835Abstract: A mesoscale data-based automatic wind turbine layout method and device. The method comprises: initially screening an input wind field region on the basis of input mesoscale wind map data by means of a wind speed limit value to obtain a first wind field region (S100); re-screening the first wind field region on the basis of input terrain data by means of a slope limit value to obtain a second wind field region (S200); and determining, by means of taboo search in which a target wind turbine count and the second wind field region are used as inputs, a wind turbine layout that optimizes an objective function (S300), wherein the objective function is the sum of the annual energy production for wind turbine locations.Type: ApplicationFiled: July 27, 2018Publication date: October 1, 2020Inventors: Chuikuan ZENG, Congcong ZHANG, Xiaolong XU
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Patent number: 10550197Abstract: The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErbB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2-specific NK-92 cell or cell line as well as to a method for identifying an ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.Type: GrantFiled: June 18, 2015Date of Patent: February 4, 2020Assignees: Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbHInventors: Winfried Wels, Kurt Schonfeld, Torsten Tonn, Manuel Grez, Congcong Zhang
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Publication number: 20180329022Abstract: A method for locating an object using cluster-type magnetic field is disclosed. The method implemented on an electronic apparatus, comprises: obtaining a wireless signal and a magnetic field signal; performing a first locating for an object according to the wireless signal; and performing a second locating for the object according to the magnetic field signal in the range of the first locating. In addition, an apparatus and a system for locating an object using cluster-type magnetic field are also disclosed. Accordingly, the present invention performs a first rough locating for an object by a wireless signal and then a precise locating for the object in the range of the first locating, thus reducing the amount of calculation, lowering computational complexity and improving accuracy of locating.Type: ApplicationFiled: July 11, 2018Publication date: November 15, 2018Inventors: Xinheng Wang, Congcong Zhang, Tao Chen
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Publication number: 20180282427Abstract: The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErhB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2-specific NK-92 cell or cell line as well as to a method for identifying au ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.Type: ApplicationFiled: February 20, 2018Publication date: October 4, 2018Applicants: CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS, DRK BLUTSPENDEDIENST BADEN-WURTTEMBERG-HESSEN GGMBHInventors: Winfried Wels, Kurt Schonfeld, Torsten Tonn, Manuel Grez, Congcong Zhang
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Patent number: 9920132Abstract: The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErbB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2-specific NK-92 cell or cell line as well as to a method for identifying an ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.Type: GrantFiled: May 19, 2017Date of Patent: March 20, 2018Assignees: Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, DRK Blutspendedienst Baden-Wurttemberg-Hessen gGmbHInventors: Winfried Wels, Kurt Schonfeld, Torsten Tonn, Manuel Grez, Congcong Zhang
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Publication number: 20170283507Abstract: The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErbB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2-specific NK-92 cell or cell line as well as to a method for identifying an ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.Type: ApplicationFiled: May 19, 2017Publication date: October 5, 2017Inventors: Winfried Wels, Kurt Schonfeld, Torsten Tonn, Manuel Grez, Congcong Zhang
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Publication number: 20170129967Abstract: The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErbB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2-specific NK-92 cell or cell line as well as to a method for identifying an ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.Type: ApplicationFiled: June 18, 2015Publication date: May 11, 2017Inventors: Winfried Wels, Kurt Schonfeld, Torsten Tonn, Manuel Grez, Congcong Zhang
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Publication number: 20170097237Abstract: A method for real-time object locating and mapping includes: 1) performing real-time locating for a moving object in the range of movement; 2) updating a geomagnetic field map in the range of movement of the object in real time according to the locating of the moving object; 3) locating the next position of the moving object according to the updated geomagnetic field map; and repeating steps 2) and 3) until the object stops moving. A device for real-time object locating and mapping is also disclosed. The present application can solve the problem of real-time object locating and accurate geomagnetic field mapping without an indoor priori magnetic field map.Type: ApplicationFiled: December 16, 2016Publication date: April 6, 2017Applicant: CHIGOO INTERACTIVE TECHNOLOGY CO., LTD.Inventors: Xinheng WANG, Congcong ZHANG, Shangjie JIA