Patents by Inventor Congxin Liang

Congxin Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
    Publication number: 20110160209
    Abstract: Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: June 18, 2009
    Publication date: June 30, 2011
    Inventors: Congxin Liang, Zhigang Li
  • P13K ISOFORM SELECTIVE INHIBITORS
    Publication number: 20110130395
    Abstract: 2-Morpholin-4-yl-9H-purine and 5-Morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine derivatives, especially those substituted by 6-heteroaryl, are unexpected PI3 kinase isoform selective inhibitors with good drug properties and are useful in treating disorders related to abnormal PI3K activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Application
    Filed: July 7, 2009
    Publication date: June 2, 2011
    Inventors: Congxin Liang, Zhigang Li
  • INHIBITORS OF FOCAL ADHESION KINASE
    Publication number: 20110046121
    Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.
    Type: Application
    Filed: March 10, 2008
    Publication date: February 24, 2011
    Applicant: The Scripps Research Institute
    Inventors: Congxin Liang, Marcel Koenig, Yuanjun He, Par Holmberg
  • Enhanced Indolinone Based Protein Kinase Inhibitors
    Publication number: 20100267719
    Abstract: Alpha-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3?-carbonyl)amino alkanoic acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: May 26, 2006
    Publication date: October 21, 2010
    Applicant: The Scripps Research Institute
    Inventors: Congxin Liang, Yangbo Feng, Tomas Vojkovsky
  • Kinase inhibitor compounds
    Publication number: 20100261665
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
    Type: Application
    Filed: January 28, 2010
    Publication date: October 14, 2010
    Applicant: Xcovery, Inc.
    Inventors: Congxin Liang, Ming Qi, Shu Gao, Zhigang Li
  • KINASE INHIBITOR COMPOUNDS
    Publication number: 20100144768
    Abstract: Pyrimidinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as inflammatory diseases and certain types of cancer.
    Type: Application
    Filed: June 5, 2008
    Publication date: June 10, 2010
    Inventor: Congxin Liang
  • Kinase inhibitor compounds
    Patent number: 7683057
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: March 23, 2010
    Assignee: Tyrogenex, Inc.
    Inventors: Congxin Liang, Ming Qi, Shu Gao, Zhigang Li
  • KINASE INHIBITOR COMPOUNDS
    Publication number: 20100063031
    Abstract: Pyridine and pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: January 18, 2008
    Publication date: March 11, 2010
    Applicant: XCOVERY, INC.
    Inventor: Congxin Liang
  • ALKOXY INDOLINONE BASED PROTEIN KINASE INHIBITORS
    Publication number: 20090305382
    Abstract: Alkoxy indolinone based acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: September 21, 2006
    Publication date: December 10, 2009
    Applicant: The Scripps Research Institute
    Inventors: Congxin Liang, Yangbo Feng
  • Alkoxy indolinone based protein kinase inhibitors
    Patent number: 7629339
    Abstract: Alkoxy indolinone based acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: December 8, 2009
    Assignee: The Scripps Research Institute
    Inventors: Congxin Liang, Yangbo Feng
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
    Patent number: 7582756
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: September 1, 2009
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • Pyrrole substituted 2-indolinone protein kinase inhibitors
    Patent number: 7572924
    Abstract: The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: August 11, 2009
    Assignees: Sugen, Inc., Pharmacia & Upjohn Co.
    Inventors: Peng Cho Tang, Todd Anthony Miller, Xiaoyuan Li, Connie Li Sun, Chung Chen Wei, Shahrzad Shirazian, Congxin Liang, Tomas Vojkovsky, Asaad S. Nematalla, Michael Hawley
  • Kinase inhibitor compounds
    Publication number: 20090076005
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
    Type: Application
    Filed: December 28, 2007
    Publication date: March 19, 2009
    Applicant: Xcovery, Inc.
    Inventors: Congxin Liang, Ming Qi, Shu Gao, Zhigang Li
  • AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS
    Publication number: 20090068718
    Abstract: Amino acid derivatives of pyrrolyl-indolinones and their amide or ester derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: December 28, 2006
    Publication date: March 12, 2009
    Inventors: Congxin Liang, Yangbo Feng
  • Amino acid derivatives of indolinone based protein kinase inhibitors
    Publication number: 20080269212
    Abstract: Amino acid derivatives of pyrrolyl-indolinones and their amide or ester derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: December 28, 2006
    Publication date: October 30, 2008
    Applicant: The Scripps Research Institute
    Inventors: Congxin Liang, Yangbo Feng
  • Advanced Indolinone Based Protein Kinase Inhibitors
    Publication number: 20080044881
    Abstract: Hydroxy carboxy pyrrolyl-indolinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: November 26, 2004
    Publication date: February 21, 2008
    Inventor: Congxin Liang
  • 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20080045709
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Application
    Filed: July 18, 2007
    Publication date: February 21, 2008
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • Thiophene Heteroaryl Amines
    Publication number: 20070293484
    Abstract: The present invention relates to thiophene heteroaryl amines and their pharmaceutically acceptable salts that modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: May 9, 2005
    Publication date: December 20, 2007
    Inventors: Huiping Guan, Connie Sun, Congxin Liang, Joanne Johnson, Lisa Bourdon, Ren Hua Song, Pavel Zhichkin
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors
    Patent number: 7256189
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: August 14, 2007
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu (Alan) Jin, Paul M. Herrinton, Michael A. Mauragis
  • Alkoxy indolinone based protein kinase inhibitors
    Publication number: 20070072934
    Abstract: Alkoxy indolinone based acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: September 21, 2006
    Publication date: March 29, 2007
    Applicant: The Scripps Research Institute
    Inventors: Congxin Liang, Yangbo Feng