Patents by Inventor Connie L. Sun

Connie L. Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis and use of kinase inhibitors
    Patent number: 9505719
    Abstract: An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: November 29, 2016
    Assignee: VERASTEM, INC.
    Inventors: Yixiong Lei, Carl Henry Behrens, Hui-Yin Li, Connie L. Sun
  • SYNTHESIS AND USE OF KINASE INHIBITORS
    Publication number: 20140235635
    Abstract: An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
    Type: Application
    Filed: August 7, 2013
    Publication date: August 21, 2014
    Applicant: PONIARD PHARMACEUTICALS, INC
    Inventors: Yixiong Lei, Carl Henry Behrens, Hui-Yin Li, Connie L. Sun
  • Piperidine and piperazine derivatives
    Patent number: 8183374
    Abstract: Compounds of general formula (Ia): in which R1, A1, m, X, n, Y and R3 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: May 22, 2012
    Assignee: M's Science Corporation
    Inventors: Connie L. Sun, Xiaoyuan Li
  • Piperidine and piperazine derivatives
    Patent number: 8071602
    Abstract: Compounds of general formula (I) in which R1, m, X, n, Y and R3 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: December 6, 2011
    Assignee: M's Science Corporation
    Inventor: Connie L. Sun
  • Piperidine and piperazine derivatives
    Publication number: 20110281890
    Abstract: Compounds of general formula (I) in which R1, m, X, n, Y and R3 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 17, 2011
    Inventor: Connie L. Sun
  • Piperazine derivatives
    Publication number: 20110269775
    Abstract: Compounds of general formula (I) in which R1 and R0 have any of the meanings given in the specification have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: July 12, 2011
    Publication date: November 3, 2011
    Inventor: Connie L. Sun
  • Piperazine derivatives
    Publication number: 20110218205
    Abstract: Compounds of general formula (I) A compound of general formula (I) in which— R1 and R0 have any of the meanings given in the specification have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: May 11, 2011
    Publication date: September 8, 2011
    Inventor: Connie L. Sun
  • BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES
    Publication number: 20110124634
    Abstract: The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.
    Type: Application
    Filed: May 8, 2009
    Publication date: May 26, 2011
    Inventors: Connie L. Sun, Xiaoyuan Li
  • RAPAMYCIN ANALOGS AS ANTI-CANCER AGENTS
    Publication number: 20110098241
    Abstract: Analogs and derivatives of rapamycin are provided, wherein the analogs and derivatives can bind to FK-506 binding protein (FKBP), or inhibit the mTOR function of an FKBP, or both. The analogs and derivatives are rapamycin include the rapamycin skeleton substituted at the 42-hydroxyl group with certain specified chemically feasible groups. Methods of using the rapamycin analogs and derivatives in treatment of malconditions such as cancer, and methods of synthesizing the rapamycin analogs and derivatives, are provided.
    Type: Application
    Filed: April 13, 2009
    Publication date: April 28, 2011
    Inventors: Connie L. Sun, Xiaoyuan Li
  • Piperazine and Piperidine Derivatives
    Publication number: 20100256162
    Abstract: Compounds of general formula (I) in which R1, m, X, n, Y and R3 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: October 10, 2006
    Publication date: October 7, 2010
    Applicant: AGY THERAPEUTICS, INC.
    Inventor: Connie L Sun
  • Piperidine and Piperazine Derivatives
    Publication number: 20100137334
    Abstract: Compounds of general formula (Ia): in which R1, A1, m, X, n, Y and R3 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: January 22, 2007
    Publication date: June 3, 2010
    Inventors: Connie L. Sun, Xiaoyuan Li
  • Piperazine Derivatives
    Publication number: 20090221607
    Abstract: Compounds of general formula (I) in which R1, A1, A2 and R2 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: January 23, 2007
    Publication date: September 3, 2009
    Applicant: M's Science Corporation
    Inventors: Connie L. Sun, Xiaoyuan Li
  • Piperazine Derivatives
    Publication number: 20090143395
    Abstract: Compounds of general formula (I) in which R1 and R0 have any of the meanings given in the specification have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.
    Type: Application
    Filed: August 2, 2006
    Publication date: June 4, 2009
    Inventor: Connie L. Sun