Patents by Inventor Connie M. Smith

Connie M. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11497414
    Abstract: A pump-less breath analysis device regulates the flow of breath past a nanoparticle sensor (or other semiconductor sensor) by dynamically adjusting the state or position of a valve as the user exhales into the device. The valve controls the flow of incoming breath between two flow paths: a venting path through which breath exits the device without passing by the nanoparticle sensor, and a sensing path that includes the nanoparticle sensor. In some embodiments, the valve is controlled by a processor that monitors pressure produced by the user's exhalation force. Based on these real-time pressure measurements, the processor adjusts the valve to maintain the pressure, and thus the flow rate, in the sensing path within a desired range. The processor may also use the pressure measurements to determine whether the characteristics of the user's exhalation are sufficient to generate a valid measurement.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: November 15, 2022
    Assignee: Invoy Holdings, Inc.
    Inventors: Zachary B. Smith, Connie Kim, Lubna M. Ahmad, Ronald J. Schoenbaum
  • Patent number: 7115594
    Abstract: This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1?,25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: October 3, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 6939868
    Abstract: This invention provides pharmaceutical uses for 2?-methyl-19-nor-20(S)-1?,25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: September 6, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Publication number: 20040072804
    Abstract: This invention provides pharmaceutical uses for 2&agr;-methyl-19-nor-20(S)-1&agr;,25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
    Type: Application
    Filed: September 29, 2003
    Publication date: April 15, 2004
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Publication number: 20040068129
    Abstract: This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1&agr;,25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
    Type: Application
    Filed: September 29, 2003
    Publication date: April 8, 2004
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Publication number: 20020151528
    Abstract: This invention provides pharmaceutical uses for 2&agr;-methyl-19-nor-20(S)-1&agr;,25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocle thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
    Type: Application
    Filed: October 19, 2001
    Publication date: October 17, 2002
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 6306844
    Abstract: This invention provides pharmaceutical uses for 2&agr;-methyl-19-nor-20(S)-1&agr;, 25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: October 23, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 6291444
    Abstract: A method for treating a T-cell immunodeficiency in a mammal by administering an amount of a vitamin D compound, such as vitamin D3, its active form 1&agr;,25-dihydroxyvitamin D3 or other compounds exhibiting vitamin D-like activity, to the mammal for a sufficient period of time to improve or restore the immunity of the mammal.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: September 18, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Shouli Yang, Jean M. Prahl, Connie M. Smith
  • Patent number: 5976784
    Abstract: A method of treating metabolic bone diseases such as osteoporosis, as well as other disease states treatable with vitamin D compounds, comprises administering an effective amount of one or more modified vitamin D compound. The modified compound contains a typical vitamin D nucleus but with in vivo hydrolyzable groups at one or more of the 1, 3 and 25 carbon positions. The time of conversion of the modified compound to its active form, such as calcitriol, can be regulated to thus provide controlled release of the compound in vivo over time, by changing or modifying the hydrolyzable groups.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: November 2, 1999
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Zu Y. Cai, Mary E. Phelps, Connie M. Smith
  • Patent number: 5880114
    Abstract: A method for treating immune deficiency in a mammal by administering an amount of a vitamin D compound, such as Vitamin D.sub.3, its active form 1.alpha.,25-dihydroxyvitamin D.sub.3 or other compounds exhibiting vitamin D-like activity, to the mammal for a sufficient period of time to improve or restore the immunity of the mammal.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 9, 1999
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. Deluca, Shouli Yang, Jean M. Prahl, Connie M. Smith
  • Patent number: 5654292
    Abstract: Compositions containing vitamin D compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, lack of dermal hydration and insufficient sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 5, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5612326
    Abstract: Homologated Vitamin-D compounds used to treat skin conditions by oral or parenteral administration.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: March 18, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5578587
    Abstract: Compositions containing one or more Vitamin D compounds selected from the group consisting of 1.alpha.-hydroxyvitamin D homolog compouns, 19-nor-vitamin C compounds and secosterol compounds useful in the treatment of various skin conditions.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: November 26, 1996
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5459136
    Abstract: Compositions containing vitamin D compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, lack of dermal hydration and insufficient sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: October 17, 1995
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5366731
    Abstract: Compositions containing secosterol compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion.
    Type: Grant
    Filed: February 3, 1993
    Date of Patent: November 22, 1994
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5276061
    Abstract: Compositions containing 1.alpha.-hydroxyvitamin D homolog compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.
    Type: Grant
    Filed: August 24, 1990
    Date of Patent: January 4, 1994
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5185150
    Abstract: Compositions containing 19-nor-vitamin D compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.
    Type: Grant
    Filed: August 24, 1990
    Date of Patent: February 9, 1993
    Assignee: Wisconsin Alumni Research Fdn.
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5151416
    Abstract: A method for controlling vertebrate pest populations such as rodents, starlings and blackbirds which comprise making available to such pest populations a vitamin D compound in a high calcium bait diet.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: September 29, 1992
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 4448726
    Abstract: This invention is directed to a new class of vitamin D compounds which are characterized by a modified ring A and triene structures and to a method for preparing same. The 7,8-dihydroxy-, 10.19-dihydroxy- and 10-oxo-19-nor-analogs of 25-hydroxyvitamin D.sub.3 are specifically disclosed.
    Type: Grant
    Filed: May 11, 1983
    Date of Patent: May 15, 1984
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Connie M. Smith