Abstract: Provided herein are compression devices and methods of use thereof, and methods of treatment for patients with edema. The compression device can include a sleeve having a plurality of inflatable chambers and at least one pneumatic pump that can be coupled to at least one inflatable chamber. The device can also include a portable bio impedance analyzer, a microcontroller and a battery. The battery can power the microcontroller and the at least one pneumatic pump and the microcontroller can control the both the portable bio impedance analyzer and the at least one pneumatic pump. The device can be used to treat a patient. Body impedance values are received from the sensors. The inflatable chambers are inflated in a sequence and to a pressure level based on the instructions from the microcontroller when the body impedance values meet a first predefined threshold.