Abstract: An exemplary method includes delivering a cardiac resynchronization therapy using an atrio-ventricular delay and an interventricular delay, monitoring patient activity, optimizing the atrio-ventricular delay and the interventricular delay for a plurality of patient activity states to generate a plurality of optimal atrio-ventricular delays and a plurality of optimal interventricular delays, storing the optimal atrio-ventricular delays and the optimal interventricular delays in association with corresponding patient activity states, detecting a change in patient activity, adjusting an atrial pacing rate in response to the detected change in patient activity based at least in part on a heart failure status and setting the atrio-ventricular delay and the interventricular delay, in response to the detected change in patient activity, using a stored optimal atrio-ventricular delay that corresponds to the patient activity and a stored optimal interventricular delay that corresponds to the patient activity.

Abstract: A specialized receptacle for receiving and for holding a fluid filled, box-style beverage container, the beverage container having flexible walls and a foil covered access port positioned on a top portion of the beverage container. The receptacle includes four planar sidewalls each integrally connected to an adjacent one of the planar sidewalls and a bottom integrally connected to at least one of the sidewalls. The combination of four planar sidewalls and bottom collectively defines a box-like structure having an internal space, and having an opening for receiving and for holding the fluid filled, box-style beverage container within the internal space. The receptacle may include handles or grooves to improve grasping; may include a hole in the bottom portion of the receptacle to facilitate removal of a beverage container; may include a top piece used to retain the beverage container in the internal space of the receptacle; and may include insulative means to insure a cool beverage product.