Abstract: Systems and methods are disclosed for predicting a biomarker status. A method of predicting a biomarker status comprises administering a battery of assessments to a patient; collecting multimodal data based on one or more responses to the battery of assessments from the patient; extracting one or more feature sets from the one or more response; providing the one or more feature sets to a trained machine learning model; predicting, using the trained machine learning model, a status of a biomarker of the patient; providing the prediction into a recommendation engine; determining one or more interventions based on the prediction, wherein the one or more interventions include values to the patient; and providing the one or more interventions as output.