Patents by Inventor Connor McBrine

Connor McBrine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacteriophage engineering via semi-synthesis
    Patent number: 11891630
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes via semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: February 6, 2024
    Inventors: Kirsty A. McFarland, Miles T. Rogers, Connor McBrine, Jason W. Holder
  • PHAGE ENGINEERING: PROTECTION BY CIRCULARIZED INTERMEDIATE
    Publication number: 20230383286
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: November 14, 2022
    Publication date: November 30, 2023
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Jason Holder
  • Phage engineering: protection by circularized intermediate
    Patent number: 11535843
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: December 27, 2022
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Jason Holder
  • Recombinant B11 bacteriophages and uses thereof
    Patent number: 10900025
    Abstract: The present disclosure provides compositions including recombinant B11 bacteriophages, methods for making the same, and uses thereof. The recombinant B11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: January 26, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • Bacteriophage engineering methods
    Patent number: 10815535
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 27, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings
  • Bacteriophage recombination followed by blockage of non-recombinant bacteriophage replication
    Patent number: 10494638
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: December 3, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Miles Rogers, Nicole Billings, Sarah Gruska, Lucas Tilley
  • RECOMBINANT B11 BACTERIOPHAGES AND USES THEREOF
    Publication number: 20190309265
    Abstract: The present disclosure provides compositions including recombinant B 11 bacteriophages, methods for making the same, and uses thereof. The recombinant B 11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 10, 2019
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • Recombinant B11 bacteriophages and uses thereof
    Patent number: 10329539
    Abstract: The present disclosure provides compositions including recombinant B11 bacteriophages, methods for making the same, and uses thereof. The recombinant B11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: June 25, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY INC.
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • BACTERIOPHAGE ENGINEERING VIA SEMI-SYNTHESIS
    Publication number: 20190048325
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes via semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 14, 2019
    Inventors: Kirsty A. McFarland, Miles T. Rogers, Connor McBrine, Jason W. Holder
  • Recombinant K1-5 bacteriophages and uses thereof
    Patent number: 10202610
    Abstract: The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 12, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Jason Holder
  • Recombinant K2 bacteriophages and uses thereof
    Patent number: 10174294
    Abstract: The present disclosure provides compositions including recombinant K2 bacteriophages, methods for making the same, and uses thereof. The recombinant K2 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 8, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Connor McBrine, Georgiana Kourepenos, Jason Holder
  • PHAGE ENGINEERING: PROTECTION BY CIRCULARIZED INTERMEDIATE
    Publication number: 20180346905
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Inventors: Connor McBrine, Jason Holder
  • BACTERIOPHAGE RECOMBINATION FOLLOWED BY BLOCKAGE OF NON-RECOMBINANT BACTERIOPHAGE REPLICATION
    Publication number: 20180223291
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 9, 2018
    Inventors: Jason Holder, Connor McBrine, Miles Rogers, Nicole Billings, Sarah Gruska, Lucas Tilley
  • RECOMBINANT K1-5 BACTERIOPHAGES AND USES THEREOF
    Publication number: 20180223262
    Abstract: The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 9, 2018
    Inventors: Connor McBrine, Jason Holder
  • BACTERIOPHAGE ENGINEERING METHODS
    Publication number: 20170283779
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Application
    Filed: March 27, 2017
    Publication date: October 5, 2017
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: JASON HOLDER, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings