Abstract: A device (10) to occlude the left atrial appendage (1) of a heart of a subject comprises an implantable occlusion apparatus (30) configured for radial expansion upon deployment to fluidically occlude the left atrial appendage, an elongated catheter member (80) having a distal end attachable to the implantable occlusion apparatus for transluminal delivery of the implantable occlusion apparatus to the left atrial appendage, a tissue energising module (20) having a plurality of electrodes (26) disposed around a circumference of the implantable occlusion apparatus in which each electrode is configured to contact a wall of the left atrial appendage at a tissue focal point upon deployment of the implantable occlusion apparatus, and an electrical controller (40) including a pulsed field energy delivery generator operably attachable to an electrical power source (50) and the plurality of electrodes and configured to energise the electrodes in a pulsed field ablation modality.

Abstract: A device for occlusion of a left atrial appendage of a heart including an implantable occlusion apparatus including a radially expansible element adjustable between a contracted orientation for transluminal delivery and a deployed orientation configured to occlude the left atrial appendage, an elongated catheter member operably and detachably attached to the implantable occlusion apparatus and configured for transluminal delivery and deployment of the occlusion apparatus in the left atrial appendage, and an energy delivery module configured for adjustment from a contracted configuration, and a deployed configuration suitable for engagement with adjacent tissue to ablate the tissue. The energy delivery module is operably attached to the elongated catheter member proximally of the radially expansible element and configured to contact and ablate a wall of the left atrium surrounding an ostium of the left atrial appendage.

Abstract: A system including an elongated catheter and an implant. The elongated catheter includes a proximal end configured for operative coupling to an electrical supply module, a distal end with a first electrical connector and a first conducting wire to electrically couple the electrical supply module with the first electrical connector. The implant includes a proximal connecting hub configured to detachably mount to the distal end of the elongated catheter, a second electrical connector configured to mate with the first electrical connector, and an active module electrically coupled to the second electrical connector. The first electrical connector is rotatably mounted to the distal end of the elongated catheter and the second electrical connector is non-rotatably attached to the proximal connecting hub of the implant and the elongated catheter can detach from the implant without rotation of the first electrical connector relative to the second electrical connector.

Abstract: A system includes an elongated catheter including a proximal end configured for operative coupling to an electrical power source, a distal end with a first electrical connector and a first conducting wire, an implant including a tissue energising module and a proximal connecting hub configured to detachably couple with the distal end of the elongated catheter. The proximal connecting hub includes a second electrical connector configured to mate with the first electrical connector and electrically couple the first electrical connector with the tissue energising module through a second conducting wire. A latch system to lock the distal end of the catheter to the proximal connecting hub arm includes an arm attached to the distal end of the catheter that is resiliently deformable such that the arm engages a sidewall of the proximal connecting hub and a locking element that is axially adjustable.