Abstract: The eye imaging system for producing images with reduced speckle artifacts may comprise a laser diode for providing a beam of radiation to the eye; a detector for collecting light returning from the eye and generating output signals in response thereto, the detector having a sensor integration time; a driver circuit for applying a modulated drive signal to the laser diode, the modulated drive signal inducing a spectral broadening of the beam of radiation during the sensor integration time. The laser diode may be a single-mode laser designed to operate at a fixed current and wavelength. The drive signal may be modulated by shaping a drive current pulse. The drive signal may be modulated by imposing an RF modulation on a drive current pulse. The drive signal may be further modulated by shaping a drive current pulse.

Abstract: A system and method for creating a composite retinal thickness map of an eye, including collecting, by an optical coherence tomography (OCT) device, a set of a plurality of optical coherence tomography (OCT) volume scans of the eye. At least one set of the plurality of OCT volume scans is collected by the OCT device by: segmenting a target upper retinal layer and a target lower retinal layer which is lower than the target upper retinal layer within an OCT volume scan; determining a thickness map of a candidate between the upper retinal layer and lower retinal layer, and a confidence map associated with the thickness map; selecting at least one thickness map as a reference thickness map; registering at least one thickness map to the reference thickness map; and selectively combining a region of the thickness map with a corresponding region of the reference thickness map to define a composite retinal thickness map.

Abstract: Various techniques for providing a low-cost ophthalmic imaging system, such an OCT or fundus imagers are presented. Cost is reduced by using a K-minor as a scanning component. The K-mirror is positioned at a retina conjugate. A beam splitter is positioned at the pupil conjugate and may be used to provide pupil splitting functionality. The beam splitter's shape and area conform to the focal light footprint of an illumination source such that it spans only a fraction of a collection window. 2D FFT is applied to capture spectra for purposes of selectively removing complex conjugate components and for extracting patient pupil to system collection pupil alignment. Consequently, pupil alignment is achieved by use of captured OCT data without the need for additional pupil cameras.

Abstract: An ophthalmic imaging system has a specialized graphical user interface GUI to convey information for manually adjusting control inputs to bring an eye into alignment with the device. The GUI provides additional information such as laterality, visual alignment overlay aids, and live video feeds. The system further applies automatic gain control to fundus images, synchronizes itself with other ophthalmic systems on a computer network, and provides an optimized image load and display system.

Abstract: Ophthalmic imaging systems, particularly slit-scanning ophthalmo-scopes, are capable of characterizing refraction over the entire field of view of the system. Light from the light source of the system illuminates a region of the eye and the returning light is measured on a detector. The deviation of the location of the returning light from a predetermined location on the detector is measured. The deviation corresponds to the mismatch between the refractions of the imaging system and the eye. The light can be scanned across the full field of view to characterize the entire field. A second illumination source traveling along a second illumination path can be used to improve the characterization. The characterization can be of use for optimizing the focus of the instrument and for assessing the condition of the eye, including assessing myopia and astigmatism in the periphery.

Abstract: An ophthalmic imaging system provides an automatic focus mechanism based on the difference of consecutive scan lines. The system also provides of user selection of a focus point within a fundus image. A neural network automatically identifies the optic nerve head in an FA or ICGA image, which may be used to determine fixation angle. The system also provides additional scan tables for multiple imaging modalities to accommodate photophobia patients and multi-spectrum imaging options.

Abstract: An ophthalmic imaging system provides a user interface to facilitate the montaging of scan images collected with various imaging modalities, such as images collected with a fundus imaging system or an optical coherence tomography (OCT) system. The amount of each constituent image used in the montage is dependent upon its respective quality. During the collecting of scans (constituent images) for montaging, any scan may be designated for rescanning, such as if its current quality is deemed less than sufficient. In the case of using an OCT system to collect constituent images (e.g., cube scans), the scanned region of a constituent image may be modified based on physical characteristics of the eye being scanned.

Abstract: An ophthalmic imaging system has a specialized graphical user interface GUI to convey information for manually adjusting control inputs to bring an eye into alignment with the device. The GUI provides additional information such as laterality, visual alignment overlay aids, and live video feeds. The system further applies automatic gain control to fundus images, synchronizes itself with other ophthalmic systems on a computer network, and provides an optimized image load and display system.

Abstract: Ophthalmic imaging systems, particularly slit-scanning ophthalmo-scopes, are capable of characterizing refraction over the entire field of view of the system. Light from the light source of the system illuminates a region of the eye and the returning light is measured on a detector. The deviation of the location of the returning light from a predetermined location on the detector is measured. The deviation corresponds to the mismatch between the refractions of the imaging system and the eye. The light can be scanned across the full field of view to characterize the entire field. A second illumination source traveling along a second illumination path can be used to improve the characterization. The characterization can be of use for optimizing the focus of the instrument and for assessing the condition of the eye, including assessing myopia and astigmatism in the periphery.

Abstract: Methods to create montages of wide-field fundus images, while correcting for the projective distortion inherent to an imaging system are described. The methods use specific knowledge of the imaging geometry of the particular imaging system to map the fundus images onto a set of 3D ray vectors, which allows them to be stitched together efficiently and precisely. After co-aligning the images using feature detection and matching, the registered images are projected back into 2D to generate the final montaged image. The method could be used on any type of wide-field fundus images including, but not limited to, those generated from optical coherence tomography, optical coherence tomography angiography, and broad-line fundus imaging systems.

Abstract: An ophthalmic imaging system provides a user interface to facilitate the montaging of scan images collected with various imaging modalities, such as images collected with a fundus imaging system or an optical coherence tomography (OCT) system. The amount of each constituent image used in the montage is dependent upon its respective quality. During the collecting of scans (constituent images) for montaging, any scan may be designated for rescanning, such as if its current quality is deemed less than sufficient. In the case of using an OCT system to collect constituent images (e.g., cube scans), the scanned region of a constituent image may be modified based on physical characteristics of the eye being scanned.

Abstract: Methods to create montages of wide-field fundus images, while correcting for the projective distortion inherent to an imaging system are described. The methods use specific knowledge of the imaging geometry of the particular imaging system to map the fundus images onto a set of 3D ray vectors, which allows them to be stitched together efficiently and precisely. After co-aligning the images using feature detection and matching, the registered images are projected back into 2D to generate the final montaged image. The method could be used on any type of wide-field fundus images including, but not limited to, those generated from optical coherence tomography, optical coherence tomography angiography, and broad-line fundus imaging systems.

Abstract: Methods and systems for imaging the fundus of the eye are disclosed, in which the fundus is illuminated through a mask which blocks light from reaching one or more masked regions within a peripheral area surrounding a target area of interest, such as the macular region. An image is obtained of both the target area and the peripheral area. A scattered light value is derived from the image intensity within the masked regions, and this is used to compensate and adjust the measured intensity of light within the target area. When employed in the measurement of macular pigment optical degeneration, an improved measurement is obtained in which the specific image(s) used for measurement have a specifically calculated correction factor applied to compensate for light scatter, rather than relying on population-based average scattering values.