Abstract: Pharmaceutical compositions comprising a PYY peptide, a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation.

Abstract: A pharmaceutical device comprising a composition comprising an aqueous solution of PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation, and wherein the composition is present in a container; and an actuator fluidly connected to the container, wherein the actuator has a tip which defines a passage through which the solution is ejected to produce a spray of the solution.

Abstract: Pharmaceutical compositions are described comprising PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol.

Abstract: A method for determining the total amount of a Y2 receptor-binding such as PYY in a blood sample. Bound PYY is first freed from components in the blood and proteinaceous material in the blood precipitated preferably by the addition of an organic solvent miscible in water such as ethanol. The PYY remains in solution in a supernatant liquid. The supernatant liquid containing the PYY is removed and the total amount of PYY contained therein is determined preferably by means of an radioimmunoassay.