Patents by Inventor Conor MCGUIRE

Conor MCGUIRE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-IgE ANTIBODIES
    Publication number: 20220177604
    Abstract: The present invention relates to antibodies that bind to IgE and their use in the treatment of autoimmune diseases, particularly Bullous Pemphigoid (BP) and Chronic Spontaneous Urticaria (CSU). The anti-IgE antibodies comprise a variant Fc domain that binds to the Fc receptor FcRn with increased affinity relative to a wild-type Fc domain. The anti-IgE antibodies may comprise a variant Fc domain comprising the amino acids Y, T, E, K, F and Y at EU positions 252, 254, 256, 433, 434 and 436, respectively, wherein the variant Fc domain binds to human FcRn with increased affinity relative to a wild-type human IgG Fc domain.
    Type: Application
    Filed: April 9, 2020
    Publication date: June 9, 2022
    Inventors: Michael SAUNDERS, Rene BIGIRIMANA, Christophe BLANCHETOT, Marijn CROMHEECKE, Conor MCGUIRE