Patents by Inventor Constance E. Brinckerhoff

Constance E. Brinckerhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Preventing Joint Destruction in Osteoarthritis
    Publication number: 20130035357
    Abstract: The present invention is methods for inhibiting collagen destruction in joints of osteoarthritis patients. The methods are based on use of rexinoid compounds, in particular bexarotene, and their activity to inhibit synthesis of matrix metalloproteinases (MMPs) in affected tissue.
    Type: Application
    Filed: April 13, 2011
    Publication date: February 7, 2013
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Richard Chou, Constance E. Brinckerhoff, Daniel A. Albert
  • Kit for diagnosing and prognosticating matrix metalloproteinase-1 related disease via a matrix metalloproteinase-1 single nucleotide polymorphism
    Patent number: 7473774
    Abstract: Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcriptions factors to the Ets transcription factor binding site created by or resulting from this single nucleotide polymorphism and methods of using these agents to treat matrix metalloproteinase-1 related diseases.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: January 6, 2009
    Assignee: Trustees of Dartmouth College
    Inventors: Constance E. Brinckerhoff, Joni L. Rutter
  • Methods of diagnosing, prognosticating and treating matrix metalloproteinase-1 related diseases via a matrix metalloproteinase-1 single nucleotide polymorphism
    Patent number: 7033756
    Abstract: Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcriptions factors to the Ets transcription factor binding site created by or resulting from this single nucleotide polymorphism and methods of using these agents to treat matrix metalloproteinase-1 related diseases.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: April 25, 2006
    Assignee: Trustees of Dartmouth College
    Inventors: Constance E. Brinckerhoff, Joni L. Rutter